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Titolo:
ADHALIN (ALPHA-SARCOGLYCAN) IS NOT REQUIRED FOR ANCHORING OF NITRIC-OXIDE SYNTHASE-I (NOS-I) TO THE SARCOLEMMA IN NONMAMMALIAN SKELETAL (STRIATED) MUSCLE-FIBERS
Autore:
GOSSRAU R; CHRISTOVA T; GROZDANOVIC Z; BLOTTNER D;
Indirizzi:
FREE UNIV BERLIN,CLIN BENJAMIN FRANKLIN,DEPT ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY MED UNIV SOFIA,DEPT ANAT & HISTOL BG-1431 SOFIA BULGARIA
Titolo Testata:
Acta histochemica
fascicolo: 3, volume: 98, anno: 1996,
pagine: 345 - 355
SICI:
0065-1281(1996)98:3<345:A(INRF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NADPH-DIAPHORASE; MUSCULAR-DYSTROPHY; COMPLEX; HISTOCHEMISTRY; EXPRESSION; PROTEIN; DOMAIN;
Keywords:
NITRIC OXIDE SYNTHASE I; NOS I; ADHALIN; ALPHA-SARCOGLYCAN; SKELETAL MUSCLE; RAT; CHICKEN; TURTLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
R. Gossrau et al., "ADHALIN (ALPHA-SARCOGLYCAN) IS NOT REQUIRED FOR ANCHORING OF NITRIC-OXIDE SYNTHASE-I (NOS-I) TO THE SARCOLEMMA IN NONMAMMALIAN SKELETAL (STRIATED) MUSCLE-FIBERS", Acta histochemica, 98(3), 1996, pp. 345-355

Abstract

Previous studies have shown the association of NOS I with the sarcolemma in mammalian striated muscle fibers, implicating the dystrophin complex (DC) as a major anchor for the enzyme. The potential role of thesarcoglycan subcomplex, especially of alpha-sarcoglycan (adhalin), aspart of the DC in holding of NOS I in the sarcolemmal position was examined by carrying out a comparative study on the distribution of NOSI, dystrophin, dystrophin-associated glycoproteins (DAG) and alpha-sarcoglycan in various skeletal muscles of non-mammals. Rat muscles were included since they reflect the situa tion in mammals. Catalytic NOS-associated diaphorase (NOSaD) activity as well as NOS I and DAG immunoreactivities were positive in the saracolemma region of skeletal muscle fibers of rats, chicken, and turtles. Adhalin immunoreactivity was present in the rat but absent in the chicken and turtle muscle surface membrane. These data suggest that alpha-sarcoglycan and therefore the entire sarcoglycan subcomplex may not be needed for localizing NOS I to the sarcolemma in these non-mammalian species. This may hold for skeletal musle fibers in general.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:15:10