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Titolo:
COLOCALIZATION OF NADPH-DIAPHORASE WITH NEUROPEPTIDES IN THE URETEROVESICAL GANGLIA OF HUMANS
Autore:
GROZDANOVIC Z; BAUMGARTEN HG;
Indirizzi:
FREE UNIV BERLIN,DEPT ANAT,KONIGIN LUISE STR 15 D-14195 BERLIN GERMANY
Titolo Testata:
Acta histochemica
fascicolo: 3, volume: 98, anno: 1996,
pagine: 245 - 253
SICI:
0065-1281(1996)98:3<245:CONWNI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; GENE-RELATED PEPTIDE; HUMAN URINARY-BLADDER; SPINAL-CORD; NERVOUS-SYSTEM; GUINEA-PIG; RAT; NERVES; INNERVATION; PATHWAYS;
Keywords:
HUMAN; NITRIC OXIDE; VASOACTIVE INTESTINAL PEPTIDE; NEUROPEPTIDE Y; CALCITONIN GENE-RELATED PEPTIDE; PELVIC GANGLIA; URETEROVESICAL JUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Z. Grozdanovic e H.G. Baumgarten, "COLOCALIZATION OF NADPH-DIAPHORASE WITH NEUROPEPTIDES IN THE URETEROVESICAL GANGLIA OF HUMANS", Acta histochemica, 98(3), 1996, pp. 245-253

Abstract

Neurones in the ureterovesical ganglion complex provide autonomic innervation to the pelvic ureter, the ureterovesical junction and the bladder trigone. We examined the distribution and peptide co-expression pattern of nitric oxide synthase (NOS) in the human ureterovesical ganglia by combining NADPH-diaphorase histochemistry with immunoreactivityfor vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), and calcitonin gene-related peptide (CGRP). Less than 20% of nerve cells in the large ganglia of the ureterovesical complex were stained for NOS activity. In elderly individuals, ganglion cells regularly exhibited conspicuous morphological alterations suggestive of degenerative changes. Most of the NOS-positive cell bodies costained for VIP-immunoreactivity. A minority of NOS-expressing cells also reacted for NPY-immunoreactivity. CGRP-immunoreactivity was present in varicose terminal-like nerve fibres which were found to encircle NOS-containing perikarya. Occasionally, NOS-positive somata were surrounded by plexiform axon terminals which immunostained for VIP or NPY. We conclude that the passage of urine across the ureterovesical junction is under relaxatory control of a local nitric oxide/VIP(NPY) pathway which may be modulated by preganglionic efferent and/or primary afferent input.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:04:27