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Titolo:
THROWING A SPANNER IN THE WORKS - ANTIBIOTICS AND THE TRANSLATION APPARATUS
Autore:
SPAHN CMT; PRESCOTT CD;
Indirizzi:
MAX PLANCK INST MOL GENET,AG RIBOSOMEN,IHNESTR 73 D-14195 BERLIN GERMANY SMITHKLINE BEECHAM COLLEGEVILLE PA 19426
Titolo Testata:
Journal of molecular medicine
fascicolo: 8, volume: 74, anno: 1996,
pagine: 423 - 439
SICI:
0946-2716(1996)74:8<423:TASITW>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
16S RIBOSOMAL-RNA; ELONGATION-FACTOR-TU; ESCHERICHIA-COLI RIBOSOMES; AMINOACYL-TRANSFER-RNA; TERNARY COMPLEX-FORMATION; CONSERVED GTPASE CENTER; PEPTIDYL-TRANSFERASE; EF-TU; CRYSTAL-STRUCTURE; BINDING-SITE;
Keywords:
ANTIBIOTICS; RIBOSOMES; RIBOSOMAL RNA; ELONGATION FACTORS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
150
Recensione:
Indirizzi per estratti:
Citazione:
C.M.T. Spahn e C.D. Prescott, "THROWING A SPANNER IN THE WORKS - ANTIBIOTICS AND THE TRANSLATION APPARATUS", Journal of molecular medicine, 74(8), 1996, pp. 423-439

Abstract

The protein synthetic machinery is essential to all living cells and is one of the major targets for antibiotics. Knowledge of the structure and function of the ribosome and its associated factors is key to understanding the mechanism of drug action. Conversely, drugs have been used as tools to probe the translation cycle, thus providing a means to further our understanding of the steps that lead to protein synthesis. Our current understanding as to how antibiotics disrupt this process is re viewed here, with particular emphasis on the prokaryotic elongation cycle and those drugs that interact with ribosomal RNAs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:05:46