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Titolo:
SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) - EARLY DIAGNOSIS, PROGNOSTIC FACTORS AND NATURAL-HISTORY
Autore:
YAQUB BA;
Indirizzi:
RIYADH MIL HOSP,DEPT NEUROSCI,POB 7897-X1006 RIYADH 11159 SAUDI ARABIA KING KHALID UNIV HOSP,DIV NEUROL RIYADH 11472 SAUDI ARABIA
Titolo Testata:
Journal of the neurological sciences
fascicolo: 2, volume: 139, anno: 1996,
pagine: 227 - 234
SICI:
0022-510X(1996)139:2<227:SSP(-E>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LEUKOCYTE INTERFERON; INTRAVENTRICULAR INTERFERON; INTRATHECAL INTERFERON; ISOPRINOSINE; MEASLES;
Keywords:
MEASLES VIRUS; SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE); PERIODIC COMPLEXES; ELECTROENCEPHALOGRAPHY (EEG); MYOCLONUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Yaqub, "SUBACUTE SCLEROSING PANENCEPHALITIS (SSPE) - EARLY DIAGNOSIS, PROGNOSTIC FACTORS AND NATURAL-HISTORY", Journal of the neurological sciences, 139(2), 1996, pp. 227-234

Abstract

We studied the value of long video-split electroencephalographic monitoring (VSEEG) in detecting myoclonus in early SSPE and evaluated the natural history and outcome-affecting factors. The 32 newly diagnosed patients had VSEEG to detect myoclonus and its correlations with EEG periodic complexes. Disease progression was monitored by a special 'outcome score'; the chi-square test and multi-variable statistics analysed the outcome score in relation to different variables, such as age atonset, sex, duration of symptoms at presentation, CSF measles antibody titre, type and interval between periodic complexes (EEG discharges). Myoclonus or atonia occurred in all patients and was time-related tothe EEG periodic complexes; in 32% of patients, myoclonus or atonia were not clinically evident. The EEG periodic complexes were of 3 types: Type I (16 patients) periodic giant delta waves; Type TI(IO patients) periodic giant delta waves intermixed with rapid spikes or fast activity; and Type III (6 patients), long spike-wave discharges interrupted by giant delta waves. Outcome score was associated with symptoms duration (P < 0.01) and EEG periodic complexes (P < 0.05). Symptom duration was inversely related to final outcome (multi-variable analysis). Long VSEEG monitoring greatly improves early diagnosis and detection ofsubtle atonia or segmental myoclonus. Prognostic factors were the type of EEG periodic complexes and duration of symptoms at presentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 00:06:15