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Titolo:
NASOPHARYNGEAL CANCER IN A LOW-RISK POPULATION - DEFINING RISK-FACTORS BY HISTOLOGICAL TYPE
Autore:
VAUGHAN TL; SHAPIRO JA; BURT RD; SWANSON GM; BERWICK M; LYNCH CF; LYON JL;
Indirizzi:
FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL MP474,1124 COLUMBIA STSEATTLE WA 98104 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 MICHIGAN STATE UNIV,CTR CANC E LANSING MI 48824 MICHIGAN STATE UNIV,COLL HUMAN MED E LANSING MI 48824 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06510 MEM SLOAN KETTERING CANC CTR NEW YORK NY 10021 UNIV IOWA,DEPT PREVENT MED & ENVIRONM HLTH IOWA CITY IA 52242 UNIV UTAH,DEPT FAMILY MED SALT LAKE CITY UT 84132
Titolo Testata:
Cancer epidemiology, biomarkers & prevention
fascicolo: 8, volume: 5, anno: 1996,
pagine: 587 - 593
SICI:
1055-9965(1996)5:8<587:NCIALP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; CHINESE SALTED FISH; CIGARETTE-SMOKING; UNITED-STATES; CARCINOMA; ASSOCIATION; MORTALITY; INFECTION; ALCOHOL; AFRICA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T.L. Vaughan et al., "NASOPHARYNGEAL CANCER IN A LOW-RISK POPULATION - DEFINING RISK-FACTORS BY HISTOLOGICAL TYPE", Cancer epidemiology, biomarkers & prevention, 5(8), 1996, pp. 587-593

Abstract

Nasopharyngeal cancer (NPC) is a major public health problem in partsof Southeast Asia and North Africa, but is rare among whites and blacks, Although infection with the EBV and genetic susceptibility appear to play large roles in high-incidence populations, migrant studies suggest that environmental factors may also be important. Aside from the high risks associated with ingestion of salted fish, surprisingly few other risk factors have been established from studies in endemic areas, We studied a low-incidence population to determine whether tobacco use, alcohol consumption, and certain medical conditions and treatmentsare related to NPC and to examine variations in risk by histology, Wereasoned that new relationships might he best identified in the absence of strong causal pathways, such as intake of preserved foods and genetic susceptibility, A population-based case-control study was conducted from 1987 to 1993 at five cancer registries in the United States: western Washington, metropolitan Detroit, Connecticut, Iowa, and Utah,Controls were identified by random digit dialing and frequency matched to the gender and age distribution of cases at each registry, Telephone interviews were completed by 231 cases and 246 controls, We observed a strong dose-response relationship between cigarette smoking and risk of differentiated squamous cell carcinoma (test for trend, P <.001), The highest risk [odds ratio (OR), 6.5; 95% confidence interval (CI), 2.0-21.3] occurred among current smokers with a history of more than 60 park-years, In contrast, there was no evidence that undifferentiated or nonkeratinizing carcinomas were associated with cigarette smoking, Similarly, a significant increase in risk was observed for the heaviest alcohol consumers (21 or more drinks/week) only for differentiated squamous cell carcinomas (OR, 2.9; 95% CI, 1.2-6.9), The associations with cigarettes and alcohol appeared to be stronger among persons 50 years or older, There was a suggestion that diagnosis with infectious mononucleosis (a marker of late infection with EBV) is linked with decreased NPC risk (OR, 0.4; 95% CI, 0.1-1.1), This report indicates that over two-thirds of differentiated squamous cell NPC cases arising in older persons in the United States can be accounted for by cigarettes and alcohol, but leaves unexplained cases arising in the young and carcinomas of undifferentiated or nonkeratinizing histology, Future studies of NPC need to take into account histology and age in evaluating these and other environmental and genetic risk factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:39:42