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Titolo:
DOPAMINE-CELL DEPOLARIZATION BLOCK AS A MODEL FOR THE THERAPEUTIC ACTIONS OF ANTIPSYCHOTIC-DRUGS
Autore:
GRACE AA; BUNNEY BS; MOORE H; TODD CL;
Indirizzi:
UNIV PITTSBURGH,CTR NEUROSCI,DEPT NEUROSCI PITTSBURGH PA 15260 UNIV PITTSBURGH,CTR NEUROSCI,DEPT PSYCHIAT PITTSBURGH PA 15260 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 06519 YALE UNIV,SCH MED,DEPT PHARMACOL NEW HAVEN CT 06519
Titolo Testata:
Trends in neurosciences
fascicolo: 1, volume: 20, anno: 1997,
pagine: 31 - 37
SICI:
0166-2236(1997)20:1<31:DDBAAM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HALOPERIDOL TREATMENT; NUCLEUS-ACCUMBENS; UNANESTHETIZED RATS; ELECTROPHYSIOLOGICAL PROFILE; SUBSTITUTED BENZAMIDES; SUBTHALAMIC NUCLEUS; BEHAVIORAL EVIDENCE; STRIATAL NEURONS; SCHIZOPHRENIA; RELEASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Grace et al., "DOPAMINE-CELL DEPOLARIZATION BLOCK AS A MODEL FOR THE THERAPEUTIC ACTIONS OF ANTIPSYCHOTIC-DRUGS", Trends in neurosciences, 20(1), 1997, pp. 31-37

Abstract

Antipsychotic drugs used in the treatment of schizophrenia have in common the property of being dopamine-receptor antagonists. However, therapid timecourse of receptor blockade produced upon drug administration does not correlate with the emergence of clinical actions, which typically require weeks of treatment to become manifest. Studies in ratshave shown that repeated antipsychotic drug treatment results in a delayed inactivation of dopamine neuron firing in the midbrain due to depolarization block. Furthermore, the therapeutic efficacy of antipsychotic drugs in humans correlates with their ability to induce depolarization block of mesolimbic dopamine neurons, whereas their potential toproduce extrapyramidal side effects correlates with their propensity for inducing depolarization block in the nigrostriatal dopamine system. Therefore, dopamine-cell depolarization block is an effective model for evaluating antipsychotic drug efficacy, and provides a potential mechanism to account for their therapeutic impact on a dysregulated dopamine system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:25:18