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Titolo:
EFFECT OF ANALOGS OF DIAMINOPIMELIC ACID ON THE MESO-DIAMINOPIMELATE-ADDING ENZYME FROM ESCHERICHIA-COLI
Autore:
AUGER G; VANHEIJENOORT J; VEDERAS JC; BLANOT D;
Indirizzi:
UNIV PARIS 11,CNRS,URA 1131,BATIMENT 432 F-91405 ORSAY FRANCE UNIV PARIS 11,CNRS,URA 1131 F-91405 ORSAY FRANCE UNIV ALBERTA,DEPT CHEM EDMONTON AB T6G 2G2 CANADA
Titolo Testata:
FEBS letters
fascicolo: 1-2, volume: 391, anno: 1996,
pagine: 171 - 174
SICI:
0014-5793(1996)391:1-2<171:EOAODA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVER-PRODUCTION; EPIMERASE; INHIBITORS; PEPTIDOGLYCAN; DEHYDROGENASE; PURIFICATION; DERIVATIVES; LIGASE; DAP;
Keywords:
MESO-DIAMINOPIMELATE-ADDING ENZYME; DIAMINOPIMELIC ACID ANALOG; MURE; PEPTIDOGLYCAN BIOSYNTHESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
G. Auger et al., "EFFECT OF ANALOGS OF DIAMINOPIMELIC ACID ON THE MESO-DIAMINOPIMELATE-ADDING ENZYME FROM ESCHERICHIA-COLI", FEBS letters, 391(1-2), 1996, pp. 171-174

Abstract

Several analogues of diaminopimelic acid (A(2)pm) were tested as substrates or inhibitors of the meso-diaminopimelate-adding enzyme from Escherichia coli. They included lanthionine derivatives, a phosphonic analogue, heterocyclic compounds, 3-fluoro-A(2)pm, 4-methylene-A(2)pm and N-hydroxy-A(2)pm. The best substrates were, in decreasing order of specific enzyme activity, (2S,3R,6S)-3-fluoro-A(2)pm, meso-lanthionine sulfoxide and N-hydroxy-A(2)pm (mixture of stereoisomers). In those cases where all the stereoisomers were available, the specificity could be described as meso much greater than DD approximate to LL. N-Hydroxy-A(2)pm (mixture of stereoisomers) strongly inhibited the addition of radioactive meso-A(2)pm to UDP-N-acetylmuramoyl-dipeptide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:50:21