Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PHARMACOKINETICS OF KANAMYCIN IN THE DEVELOPING RAT
Autore:
HENLEY CM; WEATHERLY RA; OU CN; BROWN RD;
Indirizzi:
BAYLOR COLL MED,DEPT PHARMACOL,BOBBY R ALFORD DEPT OTORHINOLARYNGOL &COMMUNICAT,1 BAYLOR PLAZA HOUSTON TX 77030 BAYLOR COLL MED,DIV NEUROSCI HOUSTON TX 77030 UNIV MICHIGAN,DEPT OTOLARYNGOL ANN ARBOR MI 48109 BAYLOR COLL MED,DEPT PATHOL HOUSTON TX 77030 LOUISIANA STATE UNIV,SCH MED,DEPT PEDIAT,CLIN PHARMACOL SECT SHREVEPORT LA 71130
Titolo Testata:
Hearing research
fascicolo: 1-2, volume: 99, anno: 1996,
pagine: 85 - 90
SICI:
0378-5955(1996)99:1-2<85:POKITD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC DISTORTION PRODUCTS; 2F1-F2 OTOACOUSTIC EMISSIONS; POSTNATAL-DEVELOPMENT; AUDITORY FUNCTION; OTOTOXICITY; GENTAMICIN; NEPHROTOXICITY; AMIKACIN; MICE; TOBRAMYCIN;
Keywords:
KANAMYCIN; PHARMACOKINETICS; DEVELOPING RAT; OTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Henley et al., "PHARMACOKINETICS OF KANAMYCIN IN THE DEVELOPING RAT", Hearing research, 99(1-2), 1996, pp. 85-90

Abstract

The developing rat is hypersensitive to aminoglycoside ototoxicity during the period of anatomical and functional development of the cochlea. Toxicity is expressed only after a few days of treatment when kanamycin is given during the most sensitive period for production of ototoxicity (postnatal days 11-20). In contrast, when the drug is administered after the 20th postnatal day, the same dose and duration of treatment do not produce an ototoxic effect, Only after prolonged treatment (e.g., greater than or equal to 20 days) is there an observed effect. We characterized the pharmacokinetics of kanamycin in the serum of 12-and 25-day-old rats and observed a greater than 2.5-fold increase in elimination half-life in the 12- versus 25-day-old rat. The longer duration half-life of kanamycin in younger rats may explain the hypersensitivity of immature mammals to aminoglycoside ototoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:37:15