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Titolo:
AGMATINE IS NOT A GOOD CANDIDATE AS ENDOGENOUS LIGAND FOR IMIDAZOLINESITES OF PANCREATIC B-CELLS AND VASCULAR BED
Autore:
BERDEU D; PUECH R; LOUBATIERESMARIANI MM; BERTRAND G;
Indirizzi:
CNRS,INSERM,CTR PHARMACOL ENDOCRINOL,UPR 9023,RUE CARDONILLE F-34094 MONTPELLIER 5 FRANCE CNRS,INSERM,CTR PHARMACOL ENDOCRINOL,UPR 9023 F-34094 MONTPELLIER 5 FRANCE FAC MED MONTPELLIER,PHARMACOL LAB,INST BIOL F-34060 MONTPELLIER FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 3, volume: 308, anno: 1996,
pagine: 301 - 304
SICI:
0014-2999(1996)308:3<301:AINAGC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN RELEASE; BINDING-SITES; SECRETION; DERIVATIVES; RECEPTORS; CHANNELS; RAT;
Keywords:
AGMATINE; EFAROXAN; IMIDAZOLINE RECEPTOR; INSULIN SECRETION; VESSEL; PANCREAS, RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
D. Berdeu et al., "AGMATINE IS NOT A GOOD CANDIDATE AS ENDOGENOUS LIGAND FOR IMIDAZOLINESITES OF PANCREATIC B-CELLS AND VASCULAR BED", European journal of pharmacology, 308(3), 1996, pp. 301-304

Abstract

In order to determine whether agmatine could be a putative endogenousligand for imidazoline receptors mediating insulin secretion and vasoconstriction, we compared its effects with those of the imidazoline, efaroxan. Agmatine exhibited a much lower potency and efficacy than efaroxan on insulin secretion from rat pancreas perfused with 8.3 mM glucose. On the other hand, in contrast to efaroxan (100 mu M), agmatine (3 mM) did not increase arginine-induced insulin release. In addition, agmatine failed to reproduce the vasoconstrictor effect of efaroxan onpancreatic vessels. These results show that agmatine does not behave like efaroxan, an agonist for the imidazoline receptors mediating insulin secretion or vasoconstriction in the pancreas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:09:37