Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN RELATIVES OF PATIENTS WITH INFLAMMATORY BOWEL-DISEASE
Autore:
PAPO M; QUER JC; PASTOR RM; GARCIAPARDO G; PRATS E; MIRAPEIX E; RODRIGUEZ R; RICHART C;
Indirizzi:
UNIV ROVIRA & VIRGILI,GASTROENTEROL SECT,HOSP JOAN XXIII,DEPT BIOCHEM,DR MALLAFRE GUASCH 4 TARRAGONA 43007 SPAIN UNIV ROVIRA & VIRGILI,DEPT INTERNAL MED,HOSP JOAN XXIII,SCH MED TARRAGONA 43007 SPAIN HOSP SAN JOAN,DEPT INTERNAL MED REUS SPAIN HOSP CLIN BARCELONA,DEPT NEPHROL BARCELONA SPAIN
Titolo Testata:
The American journal of gastroenterology
fascicolo: 8, volume: 91, anno: 1996,
pagine: 1512 - 1515
SICI:
0002-9270(1996)91:8<1512:ACAIRO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SCLEROSING CHOLANGITIS; ULCERATIVE-COLITIS; NEUTROPHIL AUTOANTIBODIES; MARKER; GLOMERULONEPHRITIS; SPECIFICITY; ANTIGENS; ANCA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M. Papo et al., "ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES IN RELATIVES OF PATIENTS WITH INFLAMMATORY BOWEL-DISEASE", The American journal of gastroenterology, 91(8), 1996, pp. 1512-1515

Abstract

Background: The occurrence of antineutrophil cytoplasmic antibodies (ANCA) has been reported more frequently than expected in healthy first-degree relatives of patients with ulcerative colitis, suggesting thatthese antibodies may represent a subclinical marker of genetic disease susceptibility. Aim: To determine the prevalence of ANCA in unaffected first-degree relatives of inflammatory bowel disease patients in a Spanish population, Methods: Three hundred and seventy sera obtained from 80 patients with inflammatory bowel disease (55 ulcerative colitis, 25 Crohn's disease), 217 unaffected first-degree relatives (157 fromulcerative colitis and 60 from Crohn's disease patients), 62 healthy controls, and 11 celiac disease patients were tested using an indirectimmunofluorescence assay, Results: Antibodies were detected in 64% ofpatients with ulcerative colitis but in only 12.5% of patients with Crohn's disease, ANCA were seldom present in their unaffected first-degree relatives (4.6%), control subjects (1.6%), and celiac disease patients (0%), Conclusions: In the Spanish population studied, antineutrophil cytoplasmic antibodies occur more commonly in ulcerative colitis than in Crohn's disease, as reported in other Caucasian populations, Moreover, their presence is not increased in their first degree relatives. These findings indicate that ANCA are not a subclinical marker of genetic susceptibility to inflammatory bowel disease in this population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:10:02