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Titolo:
INFLUENCE OF EPILEPSY AND ANTIEPILEPTIC D RUG-TREATMENT ON THE EXTEROCEPTIVE SUPPRESSION OF THE TEMPORALIS MUSCLE-ACTIVITY
Autore:
STEINHOFF BJ; FANGMEYER B; REIMERS CD; PAULUS W;
Indirizzi:
UNIV GOTTINGEN,ZENTRUMS NEUROL MED,ABT KLIN NEUROPHYSIOL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY
Titolo Testata:
EEG-EMG
fascicolo: 2, volume: 27, anno: 1996,
pagine: 65 - 69
SICI:
0012-7590(1996)27:2<65:IOEAAD>2.0.ZU;2-6
Fonte:
ISI
Lingua:
GER
Soggetto:
VOLTAGE-DEPENDENT LIMITATION; MASSETER INHIBITORY REFLEX; MOUSE CENTRAL NEURONS; JAW-OPENING REFLEX; TRIGEMINAL NEURALGIA; PARKINSONS-DISEASE; CELL-CULTURE; ACTION-POTENTIALS; SODIUM VALPROATE; BRAIN;
Keywords:
EXTEROCEPTIVE SUPPRESSION; EPILEPSY; ANTIEPILEPTIC DRUGS; SIDE EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Steinhoff et al., "INFLUENCE OF EPILEPSY AND ANTIEPILEPTIC D RUG-TREATMENT ON THE EXTEROCEPTIVE SUPPRESSION OF THE TEMPORALIS MUSCLE-ACTIVITY", EEG-EMG, 27(2), 1996, pp. 65-69

Abstract

Exteroceptive suppression (ES) of temporalis muscle activity is the electrophysiological correlate of the jaw-opening reflex and consists of the monosynaptic ES1 and the polysynaptic ES 2 components. ES 2 is supposed to be mediated by inhibiting interneurons in the bulbar formatio reticularis adjacent to the inferior trigeminal nucleus which is modulated by peripheral afferences as well as inputs from subcortical limbic structures, amaygdala, hypothalamus, orbitofrontal cortex, the big raphe nucleus and the periaquaeductal grey. We investigated the ES in 31 patients with epilepsy (age 21 to 68 years) and 20 healthy volunteers (age 21 to 57 years) to assess influences of antiepileptic drugs or the epilepsy itself. Six patients each had monotherapies with carbamazepine and phenytoin, respectively. Four patients were under valproate only whereas eleven patients were treated with combinations of two (10 patients) or more(l patient) antiepileptic drugs. In addition, four patients did not take any medication at the time of the investigation. The recordings averaged 32 consecutive rectified single stimuli on each side. The analysis of onset, duration and end of ES 1 and 2 revealed no significant differences between both groups and did not give evidence for any drug-specific or disease-specific influences on the ES. We conclude that the method is not suitable to assess therapeutic or toxic antiepileptic drug effects. Conversely, effects of antiepilepticmedication and of epileptiform activity do not have to be considered as interfering factors when interpreting results of the ES recording performed for other diagnostic reasons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:20:54