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Titolo:
ROLE OF LEUKOTRIENE-DEGRADING ENZYMES IN PULMONARY RESPONSE TO ANTIGEN INFUSION IN SENSITIZED GUINEA-PIGS IN-VIVO
Autore:
FUNAYAMA T; SEKIZAWA K; YAMAYA M; YAMAUCHI K; OHNO I; OHRUI T; TERAJIMA M; OKINAGA S; SASAKI H;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU,SEIRYO MACHI 1-1 SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT GERIATR MED,AOBA KU SENDAI MIYAGI 980 JAPAN TOHOKU UNIV,SCH MED,DEPT INTERNAL MED 1 SENDAI MIYAGI 980 JAPAN
Titolo Testata:
American journal of respiratory cell and molecular biology
fascicolo: 2, volume: 15, anno: 1996,
pagine: 260 - 267
SICI:
1044-1549(1996)15:2<260:ROLEIP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-GLUTAMYL-TRANSPEPTIDASE; AIRWAY MICROVASCULAR LEAKAGE; SLOW-REACTING SUBSTANCES; HUMAN RENAL DIPEPTIDASE; VASCULAR-PERMEABILITY; ANTAGONIST; PROFILE; ASTHMA; MODULATION; MEDIATORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
T. Funayama et al., "ROLE OF LEUKOTRIENE-DEGRADING ENZYMES IN PULMONARY RESPONSE TO ANTIGEN INFUSION IN SENSITIZED GUINEA-PIGS IN-VIVO", American journal of respiratory cell and molecular biology, 15(2), 1996, pp. 260-267

Abstract

To determine the role of leukotriene (LT)-degrading enzymes in allergic reactions, we studied the effects of inhibitors of gamma-glutamyl transpeptidase (gamma-GTP) and dipeptidases on increases in pulmonary insufflation pressure (PIP) and vascular permeability induced by ovalbumin (OA) antigen in guinea pigs sensitized to OA antigen in vivo. Vascular permeability was assessed by the amount of extravasated Evans blue dye from the trachea, main bronchi, and segmental bronchi. An intravenous (i.v.) administration of OA antigen (200 mu g/kg) caused increases in PIP and extravasated Evans blue dye, and OA antigen-induced effects were potentiated by gamma-GTP inhibitor L-serine berate (3 x 10(-5) M/kg, i.v. ) (P < 0.05) and an inhibitor of dipeptidases, L-cysteine (3 x 10(-5) M/kg, i.v. ) (P < 0.01). OA antigen-induced increases in PIP and Evans blue dye extravasation were in part inhibited by LT-receptor antagonist ONO-1078 (10(-4) M/kg, i.v.). Guinea-pig tracheal tissues contained gamma-GTP and microsomal dipeptidase activities. Histochemical and immunohistochemical studies indicate that gamma-GTP-like activity existed in the epithelium and smooth muscle, and an activity of microsomal dipeptidase was observed in the endothelial cells of microvessels and epithelium. These results suggest that LT-degrading enzymes have an important role in regulating allergic reaction in the airway in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:06:25