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Titolo:
BRAIN DISTRIBUTION OF VASOACTIVE-INTESTINAL-PEPTIDE RECEPTORS FOLLOWING REM-SLEEP DEPRIVATION
Autore:
JIMENEZANGUIANO A; GARCIAGARCIA F; MENDOZARAMIREZ JL; DURANVAZQUEZ A; DRUCKERCOLIN R;
Indirizzi:
UNIV NACL AUTONOMA MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS MEXICO CITY 04510 DF MEXICO UNIV NACL AUTONOMA MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS MEXICO CITY 04510 DF MEXICO UNIV NACL AUTONOMA MEXICO,FAC MED,DEPT FISIOL MEXICO CITY DF MEXICO
Titolo Testata:
Brain research
fascicolo: 1, volume: 728, anno: 1996,
pagine: 37 - 46
SICI:
0006-8993(1996)728:1<37:BDOVRF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS EXPRESSION; CEREBROSPINAL-FLUID CSF; PARADOXICAL SLEEP; POLYPEPTIDE VIP; RAT-BRAIN; HYPNOGENIC PROPERTIES; CAT; STEM; IMMUNOREACTIVITY; PROLACTIN;
Keywords:
VASOACTIVE INTESTINAL PEPTIDE; VIP RECEPTOR; REM SLEEP DEPRIVATION; STRESS; BRAIN-STEM; DIENCEPHALON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
A. Jimenezanguiano et al., "BRAIN DISTRIBUTION OF VASOACTIVE-INTESTINAL-PEPTIDE RECEPTORS FOLLOWING REM-SLEEP DEPRIVATION", Brain research, 728(1), 1996, pp. 37-46

Abstract

Vasoactive intestinal peptide (VIP) has been shown to increase rapid eye movement (REM) sleep in normal and insomniac animals, while the administration of anti-VIP antibodies or an antagonist of VIP receptors decreases REM sleep. In addition, recently, it has been suggested thata VIP-like substance accumulates in the CSF during waking and that itmay be involved in the production of the REM rebound normally seen following REM sleep deprivation. This evidence suggests that VIP may be important in modulating REM sleep in normal conditions and during REM sleep rebound. To determine whether VIP is involved in REM sleep homeostasis, VIP receptors of discrete brain areas was determined by autoradiography after 24 and 72 h of REM sleep deprivation (REM SD) by the water tank technique. Since this procedure has been suggested to produce some stress, an additional group adapted for 7 days to the sleep deprivation situation was tested. The results showed that REM SD producesan increase in the density of VIP receptors in several brainstem and forebrain structures at 24 h of REM SD and more so at 72 h of REM SD. Interestingly, results showed that habituation to the REM SD proceduredecreases the density of VIP receptors in some areas of the brain of the REM sleep-deprived rats. The results are discussed in terms of thepossibility that waking induces an increase of VIP receptors in several structures, which in turn are responsible for modulating REM sleep,but that stress contributes in part to VIP receptor changes.

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Documento generato il 25/02/20 alle ore 07:47:05