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Titolo:
ATOVAQUONE HAS NO EFFECT ON THE PHARMACOKINETICS OF PHENYTOIN IN HEALTHY MALE-VOLUNTEERS
Autore:
DAVIS JD; DIXON R; KHAN AZ; TOON S; ROLAN PE; POSNER J;
Indirizzi:
UNIV MANCHESTER,MEDEVAL LTD,SKELTON HOUSE,MANCHESTER SCI PK,LLOYD ST N MANCHESTER M15 6SH LANCS ENGLAND GLAXO WELLCOME RES LABS BECKENHAM KENT ENGLAND
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 2, volume: 42, anno: 1996,
pagine: 246 - 248
SICI:
0306-5251(1996)42:2<246:AHNEOT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
566C80; HYDROXYNAPHTHOQUINONE; EFFICACY; AIDS;
Keywords:
ATOVAQUONE; PHENYTOIN; PHARMACOKINETICS; DRUG INTERACTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
J.D. Davis et al., "ATOVAQUONE HAS NO EFFECT ON THE PHARMACOKINETICS OF PHENYTOIN IN HEALTHY MALE-VOLUNTEERS", British journal of clinical pharmacology, 42(2), 1996, pp. 246-248

Abstract

The potential pharmacokinetic interaction between atovaquone and phenytoin was investigated in 12 healthy male volunteers. Each volunteer received a single 600 mg oral dose of phenytoin in the two treatment periods. On one occasion phenytoin was taken alone and on the other after pre-treatment with 2000 mg atovaquone taken as two doses of 1000 mg as a microfluidized suspension. The mean (+/-s.d) peak plasma concentrations (C-max), apparent total clearance (CL/F) and terminal half-life(t(1/2)) for phenytoin when administered alone were 10.6 (1.8) mg l(-1), 24.3 (7.7) ml min(-1) and 25 (8) h, respectively. When administered together with atovaquone, phenytoin C-max, CL/F and t(1/2,z) were 10.9 (2.0) mg l(-1), 23.8 ml min(-1) and 24 (6) h, respectively. There were no statistically significant differences in any of these plasma pharmacokinetic parameters. There were also no statistically significantdifferences in the fraction of circulating drug not bound to plasma protein or urinary excretion of 5-hydroxyphenyl-phenyl-hydantoin. In conclusion, there was no effect of atovaquone on the pharmacokinetics ofphenytoin or its major metabolite after a single dose.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:20:52