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Titolo:
EFFECT OF LOCALLY APPLIED PRAZOSIN ON THE KINETICS OF THE PUPILLARY LIGHT REFLEX
Autore:
MORTLOCK SA; LANGLEY RW; BRADSHAW CM; SZABADI E;
Indirizzi:
UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT PSYCHIAT NOTTINGHAM NG7 2UH ENGLAND UNIV NOTTINGHAM HOSP,QUEENS MED CTR,DEPT PSYCHIAT NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
British journal of clinical pharmacology
fascicolo: 2, volume: 42, anno: 1996,
pagine: 236 - 238
SICI:
0306-5251(1996)42:2<236:EOLAPO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEALTHY-VOLUNTEERS;
Keywords:
PUPILLARY LIGHT REFLEX; PRAZOSIN; AMBIENT TEMPERATURE SYMPATHETIC REFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
6
Recensione:
Indirizzi per estratti:
Citazione:
S.A. Mortlock et al., "EFFECT OF LOCALLY APPLIED PRAZOSIN ON THE KINETICS OF THE PUPILLARY LIGHT REFLEX", British journal of clinical pharmacology, 42(2), 1996, pp. 236-238

Abstract

The effect of locally applied prazosin on pupillometric measures was studied in healthy volunteers, in an attempt to identify the role of alpha(1)-adrenoceptors in the recovery time of the light reflex. Prazosin antagonized the mydriatic effect of phenylephrine, but did not alter that of tropicamide. Miotic responses to a range of light stimuli were measured under ambient temperature conditions of 22 degrees C and 40 degrees C. The 40 degrees C condition was associated with shorter recovery times of the light reflex; prazosin increased the recovery timeunder both temperature conditions. Response amplitude was not affected by the temperature condition or prazosin. The results are consistentwith the hypothesis that sympathetic neuromuscular transmission is involved in the redilatation of the pupil following a miotic response tolight stimulation.

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Documento generato il 09/04/20 alle ore 07:44:04