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Titolo:
SEPARATE PATHWAYS FOR P53 INDUCTION BY IONIZING-RADIATION AND N-(PHOSPHONOACETYL)-L-ASPARTATE
Autore:
CHEN CYM; HALL I; LANSING TJ; GILMER TM; TLSTY TD; KASTAN MB;
Indirizzi:
JOHNS HOPKINS UNIV HOSP,720 RUTLAND AVE,345 ROSS BLDG BALTIMORE MD 21205 JOHNS HOPKINS ONCOL CTR BALTIMORE MD 21205 UNIV CALIF SAN FRANCISCO,DEPT PATHOL SAN FRANCISCO CA 94143 GLAXO WELLCOME RES & DEV RES TRIANGLE PK NC 27709
Titolo Testata:
Cancer research
fascicolo: 16, volume: 56, anno: 1996,
pagine: 3659 - 3662
SICI:
0008-5472(1996)56:16<3659:SPFPIB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
WILD-TYPE P53; TRANSCRIPTIONALLY ACTIVE P53; P53-DEPENDENT G(1) ARREST; CYCLE CHECKPOINT PATHWAY; DNA-DAMAGE; ATAXIA-TELANGIECTASIA; GENE AMPLIFICATION; CELLULAR-RESPONSE; HUMAN FIBROBLASTS; GROWTH ARREST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C.Y.M. Chen et al., "SEPARATE PATHWAYS FOR P53 INDUCTION BY IONIZING-RADIATION AND N-(PHOSPHONOACETYL)-L-ASPARTATE", Cancer research, 56(16), 1996, pp. 3659-3662

Abstract

The tumor suppressor gene product, p53, appears to be a significant participant in signaling pathways that mediate cellular responses to cytotoxic stresses. In particular, p53 appears to be a critical determinant of whether the cell lives or dies and how it progresses through the cell cycle after the cytotoxic exposure, Many of the molecular details for these signaling pathways remain to be elucidated, and whether all cytotoxic signals utilize the same pathway to increase p53 expression is not clear, Here, we demonstrate the existence of cell types in which the induction of p53 and associated G(1) arrest by the antimetabolite, N-(phosphonoacetyl)-L-aspartate (PALA), is defective, whereas p53 induction and G(1) arrest induced by ionizing radiation are intact, These observations demonstrate the existence of genetic defects that can alter p53 induction and associated cellular outcomes after some, but not all, cytotoxic insults and suggest distinct pathways of p53 induction by PALA and ionizing radiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:46:58