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Titolo:
SOMATIC AND GERMLINE MUTATIONS OF THE BRCA2 GENE IN SPORADIC OVARIAN-CANCER
Autore:
FOSTER KA; HARRINGTON P; KERR J; RUSSELL P; DICIOCCIO RA; SCOTT IV; JACOBS I; CHENEVIXTRENCH G; PONDER BAJ; GAYTHER SA;
Indirizzi:
ADDENBROOKES HOSP,CANC RES CAMPAIGN,HUMAN CANC GENET RES GRP,HILLS RD,BOX 238 CAMBRIDGE CB2 2QQ ENGLAND ADDENBROOKES HOSP,CANC RES CAMPAIGN,HUMAN CANC GENET RES GRP CAMBRIDGE CB2 2QQ ENGLAND QUEENSLAND INST MED RES BRISBANE QLD 4006 AUSTRALIA ROSWELL PK CANC INST,DEPT GYNECOL ONCOL RES BUFFALO NY 14263 DERBY CITY GEN HOSP,DEPT OBSTET & GYNAECOL DERBY DE22 3NE ENGLAND ST BARTHOLOMEWS HOSP,ROYAL HOSP NATL HLTH SERV TRUST,OVARIAN CANC SCREENING UNIT LONDON EC1A 7BE ENGLAND
Titolo Testata:
Cancer research
fascicolo: 16, volume: 56, anno: 1996,
pagine: 3622 - 3625
SICI:
0008-5472(1996)56:16<3622:SAGMOT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSCEPTIBILITY GENE; CHROMOSOME 13Q12-13; ALLELIC LOSS; BREAST; HETEROZYGOSITY; CARCINOMAS; TUMORS; LOCUS; REGION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K.A. Foster et al., "SOMATIC AND GERMLINE MUTATIONS OF THE BRCA2 GENE IN SPORADIC OVARIAN-CANCER", Cancer research, 56(16), 1996, pp. 3622-3625

Abstract

The breast and ovarian cancer susceptibility gene BRCA2 has recently been isolated, A role for BRCA2 in sporadic breast and ovarian cancer has been suggested by loss of heterozygosity (LOH) studies which show frequent LOH in the BRCA2 region at chromosome 13q12, In addition, theobservation of nonrandom loss of the wild-type chromosome in a breast/ovarian cancer family which shows linkage to BRCAZ suggests it may act as a tumor suppressor gene, To determine the extent of somatic alteration involving BRCA2 in sporadic ovarian cancer, 50 tumors were analyzed for mutations throughout the entire BRCA2 coding region, Mutationspredicted to result in truncation of the BRCAZ protein were detected in four rumors, Analysis of germline DNA revealed two of these alterations to be of somatic origin. In addition, ail four tumors exhibited loss of the second BRCA2 allele as predicted by Knudson's hypothesis for a tumor suppressor gene, These results suggest that, as Is the case with BRCA1, somatic mutations of BRCA2 are infrequent in sporadic ovarian cancer, despite the relatively high frequency of LOH detected around the BRCA2 locus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:36:19