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Titolo:
THE SAFETY AND EFFICACY OF RANITIDINE BISMUTH CITRATE IN COMBINATION WITH ANTIBIOTICS FOR THE ERADICATION OF HELICOBACTER-PYLORI
Autore:
WYETH JW; POUNDER RE; DUGGAN AE; OMORAIN CA; SCHAUFELBERGER HD; DEKOSTER EH; RAUWS EAJ; BARDHAN KD; GILVARRY J; BUCKLEY MJM; GUMMETT PA; LOGAN RPH;
Indirizzi:
UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT MED,ROWLAND HILL ST LONDON NW3 2PF ENGLAND UNIV LONDON,ROYAL FREE HOSP,SCH MED,DEPT MED LONDON NW3 2PF ENGLAND GLAXO WELLCOME RES & DEV LTD UXBRIDGE MIDDX ENGLAND TRINITY COLL DUBLIN,MEATH HOSP DUBLIN IRELAND TRINITY COLL DUBLIN,ADELAIDE HOSP DUBLIN IRELAND CENT MIDDLESEX HOSP LONDON NW10 7NS ENGLAND BRUGMANN UNIV HOSP BRUSSELS BELGIUM UNIV AMSTERDAM,ACAD MED CTR NL-1105 AZ AMSTERDAM NETHERLANDS ROTHERHAM DIST GEN HOSP ROTHERHAM S YORKSHIRE ENGLAND
Titolo Testata:
Alimentary pharmacology & therapeutics
fascicolo: 4, volume: 10, anno: 1996,
pagine: 623 - 630
SICI:
0269-2813(1996)10:4<623:TSAEOR>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GR122311X; ULCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Wyeth et al., "THE SAFETY AND EFFICACY OF RANITIDINE BISMUTH CITRATE IN COMBINATION WITH ANTIBIOTICS FOR THE ERADICATION OF HELICOBACTER-PYLORI", Alimentary pharmacology & therapeutics, 10(4), 1996, pp. 623-630

Abstract

Background: Ranitidine bismuth citrate is a novel salt of ranitidine and a bismuth citrate complex, It has intrinsic antisecretory and anti-Helicobacter pylori activity, but monotherapy rarely eradicates H. pylori infection in man. Aim: A pilot study to investigate rates of H. pylori eradication achieved by co-prescription of ranitidine bismuth citrate with antibiotics, and to identify several regimens which would merit further investigation. Method: One hundred dyspeptic patients infected with H. pylori were randomly allocated to treatment with ranitidine bismuth citrate 800 mg b.d. plus either amoxycillin, metronidazole, clarithromycin, cefuroxime axetil, tetracycline, tetracycline plus metronidazole or clarithromycin plus tetracycline for 14 days, Eradication of infection was assessed using the C-13-urea breath test 4 weeks after the end of treatment. Results: In a per protocol analysis eradication of H. pylori ranged between 22 and 100%: the intention-to-treat eradication rates ranged between 15 and 92%, No adverse events were specifically attributed to ranitidine bismuth citrate,Conclusion: Co-prescription therapy, using ranitidine bismuth citrate and one or more antibiotics, is suitable for further investigation in large-scale clinical trials inpatients infected with H. pylori.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:38:54