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Titolo:
REVIEW ARTICLE - CLINICAL ASPECTS OF HELICOBACTER-PYLORI ERADICATION THERAPY IN PEPTIC-ULCER DISEASE
Autore:
PENSTON JG;
Indirizzi:
13 NEWHALL GARDENS DUNDEE DD2 1TW SCOTLAND
Titolo Testata:
Alimentary pharmacology & therapeutics
fascicolo: 4, volume: 10, anno: 1996,
pagine: 469 - 486
SICI:
0269-2813(1996)10:4<469:RA-CAO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
OMEPRAZOLE PLUS AMOXICILLIN; DOUBLE-BLIND TRIAL; COLLOIDAL BISMUTH SUBCITRATE; RANDOMIZED CONTROLLED TRIAL; HIGH-DOSE OMEPRAZOLE; TERM TRIPLE THERAPY; REFRACTORY DUODENAL-ULCERS; 12-MONTH FOLLOW-UP; ANTIBACTERIAL TREATMENT; GASTRIC-ULCER;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
197
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Penston, "REVIEW ARTICLE - CLINICAL ASPECTS OF HELICOBACTER-PYLORI ERADICATION THERAPY IN PEPTIC-ULCER DISEASE", Alimentary pharmacology & therapeutics, 10(4), 1996, pp. 469-486

Abstract

Background and aims: Although the role of H. pylori in peptic ulcer disease is no longer in dispute, certain aspects of eradication therapyin this condition have yet to be settled. Uncertainties still surround the relationship between Helicobacter pylori status and ulcer healing, the efficacy of eradication therapy in alleviating acute symptoms and healing ulcers, and the prognosis after eradication with respect torecurrence of symptoms, ulcers and complications. The present literature review, encompassing studies published up to October 1995, specifically addresses these issues. Results: Pooled data show that eradication therapy heals greater than or equal to 90% of duodenal ulcers and greater than or equal to 85 % of gastric ulcers, while individual studies repeatedly confirm that it is more effective at healing ulcers thanconventional treatment with anti-secretory drugs. Recent reports indicate that triple therapy regimens for 1 week, provided they include ananti-secretory drug, are sufficient to achieve high rates of healing and rapid symptom relief. A detailed analysis of the data, particularly those from studies reporting healing rates in relation to H. pylori status after eradication therapy, provides strong evidence that eradication of H. pylori produces ulcer healing. Follow-up studies show thatulcer recurrence and complications are rare after eradication treatment in patients with either gastric or duodenal ulcer disease. However,while ulcer symptoms are infrequent during follow-up, a proportion ofpatients appear to develop gastrooesophageal reflux after eradication. Conclusions: H. Pylori eradication is highly effective in promoting ulcer healing and preventing subsequent ulcer recurrence. These beneficial effects of eradication therapy are observed in patients with either gastric or duodenal ulcers which are associated with H. pylori infection.

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Documento generato il 01/12/20 alle ore 10:44:54