Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACQUIRED IMMUNOBULLOUS DISEASE - A CUTANEOUS MANIFESTATION OF IGM MACROGLOBULINEMIA
Autore:
WHITTAKER SJ; BHOGAL BS; BLACK MM;
Indirizzi:
ST THOMAS HOSP,UMDS,ST JOHNS INST DERMATOL LONDON SE1 7EH ENGLAND
Titolo Testata:
British journal of dermatology
fascicolo: 2, volume: 135, anno: 1996,
pagine: 283 - 286
SICI:
0007-0963(1996)135:2<283:AID-AC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODIES; LEUKEMIA; SKIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Whittaker et al., "ACQUIRED IMMUNOBULLOUS DISEASE - A CUTANEOUS MANIFESTATION OF IGM MACROGLOBULINEMIA", British journal of dermatology, 135(2), 1996, pp. 283-286

Abstract

Waldenstrom's macroglobulinaemia has been associated with a variety of cutaneous manifestations. We report a patient with an acquired bullous disorder associated with skin fragility and IgM kappa paraprotein. Immunofluorescence studies demonstrated bright linear deposition of IgM along the basement membrane zone (BMZ), around dermal blood vessels and on arrector pill muscles. Weak keratinocyte cell surface staining with IgM was also noted, There was no deposition of complement or other immunoglobulins. Indirect immunofluorescent studies revealed a circulating IgM anti-BMZ antibody (titre 1/200), which bound to both the roof and the Boor of a 1 mol/l NaCl split skin substrate, Immunoblottinganalysis of the patient's serum, with both epidermal and dermal extracts, was negative. Treatment with a combination of prednisolone and azathioprine was successful, We suggest that this IgM kappa paraprotein has a low affinity for an undefined epitope within the lamina lucida, which has produced a subepidermal bullous disorder associated with skin fragility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:26:47