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Titolo:
DIFFERENCES IN ACTION OF TOPICAL AND SYSTEMIC CYSTEAMINE ON GASTRIC BLOOD-FLOW, GASTRIC-ACID SECRETION AND GASTRIC-ULCERATION IN THE RAT
Autore:
ABDELSALAM OME; SZOLCSANYI J; MOZSIK G;
Indirizzi:
MED UNIV PECS,DEPT MED 1,IFJUSAG UT 13 H-7643 PECS HUNGARY MED UNIV PECS,DEPT MED 1 H-7643 PECS HUNGARY MED UNIV PECS,DEPT PHARMACOL H-7643 PECS HUNGARY
Titolo Testata:
JOURNAL OF PHYSIOLOGY-PARIS
fascicolo: 2, volume: 90, anno: 1996,
pagine: 63 - 73
SICI:
0928-4257(1996)90:2<63:DIAOTA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SENSITIVE AFFERENT NEURONS; MUCOSAL DAMAGE; INTRAGASTRIC CAPSAICIN; PERIPHERAL ENDINGS; SENSORY NEURONS; DUODENAL ULCERS; BILE-SALTS; SOMATOSTATIN; PROTECTION;
Keywords:
GASTRIC MICROCIRCULATION; LASER DOPPLER FLOWMETRY; CYSTEAMINE; CAPSAICIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
O.M.E. Abdelsalam et al., "DIFFERENCES IN ACTION OF TOPICAL AND SYSTEMIC CYSTEAMINE ON GASTRIC BLOOD-FLOW, GASTRIC-ACID SECRETION AND GASTRIC-ULCERATION IN THE RAT", J PHYSL-PAR, 90(2), 1996, pp. 63-73

Abstract

The effect of cysteamine on gastric blood flow and on the indomethacin-induced gastric mucosal damage was studied. In anesthetized rats, cysteamine (280 mg/kg) given subcutaneously (sc) decreased gastric bloodflow measured by the laser Doppler flowmetry technique. In contrast, cysteamine (1-60 mg/ml) applied topically to the serosal surface of the stomach evoked a concentration-dependent and long-lasting increase in gastric blood flow. At 60 mg/ml, cysteamine increased blood flow by 166.8 +/- 26.1% of predrug control value. Pretreatment with indomethacin (20 mg/kg, sc), intravenous (iv) atropine (1 mg/kg), propranolol (1mg/kg, iv), combined H-1 and H-2-blockade or bilateral cervical vagotomy alone or combined with iv guanethidine (8 mg/kg), or pretreatment with the capsaicin analogue resiniferatoxin did not reduce the vasodilator response to cysteamine. The vasodilator response to topical capsaicin, was not reduced after sc cysteamine (280 mg/kg) pretreatment. Inconscious pylorus-ligated rats, sc cysteamine (100 or 280 mg/kg) given simultaneously with indomethacin inhibited gastric acid output but had variable effects on the indomethacin-induced gastric mucosal damage. Cysteamine (100 or 280 mg/kg) administered sc 4 h prior to indomethacin enhanced gastric injury by sc indomethacin, but did not prevent the gastroprotective action of capsaicin. In contrast, orally administered cysteamine (60 mg/ml) reduced gastric injury induced by sc indomethacin plus intragastric HCl. These data provide the first evidence for the effect of cysteamine on gastric microcirculation in the rat and suggest a direct vasodilator effect for topical cysteamine. The microvascular effects of cysteamine are largely responsible for the different effects of this agent on experimental gastric injury.

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Documento generato il 30/11/20 alle ore 07:17:38