Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PYY IN DEVELOPING MURINE ISLET CELLS - COMPARISONS TO DEVELOPMENT OF ISLET HORMONES, NPY, AND BRDU INCORPORATION
Autore:
JACKEROTT M; OSTER A; LARSSON LI;
Indirizzi:
STATENS SERUM INST,DEPT MOL CELL BIOL,ARTILLERIVEJ 5,BLDG 81 DK-2300 COPENHAGEN S DENMARK STATENS SERUM INST,DEPT MOL CELL BIOL DK-2300 COPENHAGEN S DENMARK
Titolo Testata:
The Journal of histochemistry and cytochemistry
fascicolo: 8, volume: 44, anno: 1996,
pagine: 809 - 817
SICI:
0022-1554(1996)44:8<809:PIDMIC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC ENDOCRINE-CELLS; HUMAN FETAL PANCREAS; NEUROPEPTIDE-Y; MULTIPLE ANTIGENS; POLYPEPTIDE; EXPRESSION; INSULIN; PEPTIDE; PROGENITOR; GLUCAGON;
Keywords:
PEPTIDE YY; NEUROPEPTIDE Y; PANCREATIC POLYPEPTIDE; PANCREAS; RAT; MOUSE; DEVELOPMENT; CELL PROLIFERATION; BROMODEOXYURIDINE; IMMUNOCYTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Jackerott et al., "PYY IN DEVELOPING MURINE ISLET CELLS - COMPARISONS TO DEVELOPMENT OF ISLET HORMONES, NPY, AND BRDU INCORPORATION", The Journal of histochemistry and cytochemistry, 44(8), 1996, pp. 809-817

Abstract

Exhaustive characterizations of antisera to the structurally related peptides pancreatic polypeptide (PP), neuropeptide Y (NPY), and peptide YY (PYY) enabled us to establish the developmental pattern of these peptides in rat and mouse pancreas. PYY was the earliest detectable peptide and was present in all early appearing endocrine cell types, NPYappeared later and occurred exclusively in a subpopulation of insulincells, whereas PP cells arose latest. At the earliest stage studied, all endocrine cells stored PYY, Most of these cells also contained glucagon. Subsequently, the endocrine cells comprised glucagon + PYY cells and glucagon + PYY + insulin cells, Later, cells storing either onlyinsulin or insulin + PYY appeared. Quantitations of the relative numbers of these cell populations during development were consistent with a precursor role of triple-positive (insulin + glucagon + PYY) tells, Moreover, bromodeoxyuridine (BrdU) injections at E15.5 showed that a large percentage of triple-positive cells were in S-phase and thereforewere actively dividing, whereas almost no pure insulin cells or insulin + PYY cells synthesized DNA at this time, These results suggest that PYY-positive endocrine cells may represent precursors for mature islet cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:10:01