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Titolo:
DISCREPANCY BETWEEN CYTOTOXICITY, PLATINUM ACCUMULATION, AND DNA PLATINATION IN MCF-7 BREAST-CANCER CELLS TREATED WITH DIAQUA(1,2-DIPHENYLETHYLENEDIAMINE) PLATINUM(II) SULFATES AND CISPLATIN
Autore:
LUX F; HOLLSTEIN M; REILE H; BERNHARDT G; SCHONENBERGER H;
Indirizzi:
TECH UNIV MUNICH,INST RADIOCHEM,WALTHER MEISSNER STR 3 D-85748 GARCHING GERMANY UNIV REGENSBURG,INST PHARM D-93040 REGENSBURG GERMANY
Titolo Testata:
Biological trace element research
fascicolo: 1-3, volume: 53, anno: 1996,
pagine: 113 - 128
SICI:
0163-4984(1996)53:1-3<113:DBCPAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUTRON-ACTIVATION ANALYSIS; INHIBITING )1,2-BIS(FLUOROPHENYL)ETHYLENEDIAMINE>PLATINUM(II); NOBLE-METALS; CHEMOSENSITIVITY; SEPARATION; CARCINOMA; BINDING; LINE;
Keywords:
CISPLATIN ANALOGS; MCF-7 CELLS; CHEMOSENSITIVITY; NEUTRON ACTIVATION ANALYSIS; INTRACELLULAR PLATINUM ACCUMULATION; PLATINATION OF GENOMIC DNA;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F. Lux et al., "DISCREPANCY BETWEEN CYTOTOXICITY, PLATINUM ACCUMULATION, AND DNA PLATINATION IN MCF-7 BREAST-CANCER CELLS TREATED WITH DIAQUA(1,2-DIPHENYLETHYLENEDIAMINE) PLATINUM(II) SULFATES AND CISPLATIN", Biological trace element research, 53(1-3), 1996, pp. 113-128

Abstract

Cisplatin (cis), raceme-diaqua[1,2-bis(4-fluorophenyl)ethylenedi amine]platinum(II) sulfate (r-4F-PtSO4), ,2-bis(4-fluorophenyl)ethylenediamine]platinum(II) sulfate (m-4F-PtSO4), and -bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine] platinum(II) sulfate (m-2,6Cl(2)-4OH-PtSO4) were compared with regard to their growth inhibitory effect on MCF-7 breast cancer cells. At concentrations of 5 mu M, cis, r-4F-PtSO4, and m-4F-PtSO4 were essentially equiactive, whereas m-2,6Cl(2)-4OH-PtSO4 was ineffective. Platinum measurements by neutron activation analysis showed that a 24-h treatment of the MCF-7 cells with r-4F-PtSO4 and m-4F-PtSO4 caused a 22.3- and 10.3-fold accumulation, respectively, whereas the accumulation factors for cis (2.55) and m-2,6Cl(2)-4OH-PtSO4 (1.83) were very low. The comparison of DNA-associated platinum revealed a similar tendency. After 24 h of drug exposure, the base pair/platinum ratios were: 2.1 . 10(4) for r-4F-PtSO4, 3.7 . 10(4) for m-4F-PtSO4,6.1 . 10(4) for cisplatin, and 8.1 . 10(4) for m-2,6Cl(2)-4OH-PtSO4. Thus, the grade of cytotoxicity was correlated neither with the extentof cellular platinum enrichment nor with the degree of genomic DNA platination.

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Documento generato il 21/09/20 alle ore 03:32:48