Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ANTIGEN-PROCESSING POLYMORPHISMS IN CHRONIC HEPATITIS-C INFECTION
Autore:
HOHLER T; GERKEN G; SCHNEIDER PM; ZUMBUSCHENFELDE KH; RITTNER C;
Indirizzi:
UNIV MAINZ,INST RECHTSMED,PULVERTURM 3 D-55131 MAINZ GERMANY UNIV MAINZ,INST RECHTSMED D-55131 MAINZ GERMANY UNIV MAINZ,DEPT MED 1 D-55131 MAINZ GERMANY
Titolo Testata:
Experimental and clinical immunogenetics
fascicolo: 1, volume: 13, anno: 1996,
pagine: 7 - 11
SICI:
0254-9670(1996)13:1<7:APICHI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATOCELLULAR DAMAGE; VIRUS-INFECTION; MHC; TAP; EXPRESSION; TRANSPORT; MUTATIONS; VARIANTS; SSCP;
Keywords:
HEPATITIS C; ANTIGEN PROCESSING; TRANSPORTER ASSOCIATED WITH ANTIGEN PROCESSING; LOW-MOLECULAR-WEIGHT PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
T. Hohler et al., "ANTIGEN-PROCESSING POLYMORPHISMS IN CHRONIC HEPATITIS-C INFECTION", Experimental and clinical immunogenetics, 13(1), 1996, pp. 7-11

Abstract

Background. Cytotoxic T cell (CTL) responses may influence the courseof a hepatitis C infection. CTL recognize viral peptides on HLA classI molecules. Antigenic peptides for class I presentation are generated by proteasomes and transported into the endoplasmic reticulum by theTAP proteins. It is unknown whether polymorphisms of the antigen-processing genes might influence the development of chronic hepatitis C. Methods. 75 patients with chronic hepatitis C and 99 unrelated controlswere typed for TAP and LMP2 polymorphisms. Typing was done by allele-specific PCR techniques and PCR with subsequent single-stranded confirmation polymorphism (SSCP) analysis. Results. Apart from minor increases of the TAP20101 allele and LMP2 heterozygotes in the chronic hepatitis group there were no statistically significant differences betweenthe two groups. Conclusions. These findings suggest, that disease association for chronic hepatitis C does not extend beyond the HLA-DQ locus. Although TAP and LMP play an important role in the processing of viral antigens, their limited polymorphisms do not show any associationwith the development of chronic hepatitis C.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:45:06