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Titolo:
ANALYTICAL APPLICATION OF ATOMIC-ABSORPTION SPECTROMETRY FOR THE DETERMINATION OF CHLORPHENIRAMINE MALEATE AND CHLORPHENOXAMINE HYDROCHLORIDE IN PURE FORM AND IN PHARMACEUTICAL PREPARATIONS
Autore:
ISSA YM; AMIN AS;
Indirizzi:
CAIRO UNIV,FAC SCI,DEPT CHEM GIZA EGYPT BENHA UNIV,FAC SCI,DEPT CHEM BANHA EGYPT
Titolo Testata:
Analusis
fascicolo: 4, volume: 24, anno: 1996,
pagine: 139 - 142
SICI:
0365-4877(1996)24:4<139:AAOASF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYDRALAZINE; ANTAZOLINE; AMILORIDE; CAFFEINE;
Keywords:
ATOMIC ABSORPTION SPECTROMETRY; CHLORPHENIRAMINE MALEATE; CHLORPHENOXAMINE HCL; AMMONIUM REINECKATE; SODIUM COBALTINITRITE; PHARMACEUTICAL PREPARATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
Y.M. Issa e A.S. Amin, "ANALYTICAL APPLICATION OF ATOMIC-ABSORPTION SPECTROMETRY FOR THE DETERMINATION OF CHLORPHENIRAMINE MALEATE AND CHLORPHENOXAMINE HYDROCHLORIDE IN PURE FORM AND IN PHARMACEUTICAL PREPARATIONS", Analusis, 24(4), 1996, pp. 139-142

Abstract

A new simple, accurate, precise and sensitive indirect method for thedetermination of chloropheniramine maleate (CPRM) and chlorophenoxamine HCl (CPX HCl) using atomic absorption spectrometry has been developed. The method is based on precipitation of the ion associates formed by the reaction of CPRM or CPX HCl with ammonium reineckate and/or sodium cobaltinitrite. The solubility of the solid complexes at the optimum conditions of pH and ionic strength values have been studied. Saturated solutions of each ion-associate were prepared under the optimum conditions and the metal ion-content in the supernatant was determined. The solubility products were thus calculated at different temperatures and the thermodynamic parameters Delta H, Delta G and Delta S were determined. The method has been used for the determination of 15.6-156.4 and 13.6-136.1 mu g/mL of CPRM and CPX HCl, respectively using ammonium reineckate and 23.4-234.5 and 20.4-204.2 mu g/mL, using sodium cobaltinitrite. The method developed was applied for analysis of bulk drugs and some of their pharmaceutical preparations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:36:48