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Titolo:
DNA-REPLICATION INITIATION BY 6-DMAP TREATMENT IN MATURING OOCYTES AND DIVIDING EMBRYOS FROM MARINE-INVERTEBRATES
Autore:
NEANT I; DUBE F;
Indirizzi:
ECOLE NORMALE SUPER LYON,BIOL CELLULAIRE & MOL LAB,46 ALLEE ITALIE F-69364 LYON 07 FRANCE HOP MAISON NEUVE ROSEMONT,CTR RECH MONTREAL PQ CANADA UNIV QUEBEC,DEPT OCEANOG RIMOUSKI PQ G5L 3A1 CANADA
Titolo Testata:
Molecular reproduction and development
fascicolo: 4, volume: 44, anno: 1996,
pagine: 443 - 451
SICI:
1040-452X(1996)44:4<443:DIB6TI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE ACTIVITY; XENOPUS EGG EXTRACTS; CELL-FREE SYSTEM; S-PHASE; TYROSINE PHOSPHORYLATION; PATELLA-VULGATA; FISSION YEAST; SPISULA-SOLIDISSIMA; METAPHASE ARREST; CDC25 PROTEIN;
Keywords:
MARINE INVERTEBRATES; MEIOSIS; EARLY MITOSIS; DNA REPLICATION; P34(CDC2) TYROSINE PHOSPHORYLATION; 6-DMAP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
I. Neant e F. Dube, "DNA-REPLICATION INITIATION BY 6-DMAP TREATMENT IN MATURING OOCYTES AND DIVIDING EMBRYOS FROM MARINE-INVERTEBRATES", Molecular reproduction and development, 44(4), 1996, pp. 443-451

Abstract

6-dimethylaminopurine (6-DMAP), a potent protein kinase inhibitor, drives most cells into an interphasic stage. Experiments were undertakenwith oocytes from three marine invertebrate species, i.e., Mytilus edulis, Spisula solidissima, and Strongylocentrotus droebachiensis, wherein oocytes were arrested at different phases of meiosis. 6-DMAP induced a continuous DNA synthesis in meiotic cells, whereas it allowed a single round of DNA replication in treated mitotic cells, regardless ofspecies considered. The effects of 6-DMAP were accompanied in all cases by rephosphorylation on tyrosine of the p34(cdc2) homolog, the M-phase promoting factor (MPF) catalytic subunit. The fact that 6-DMAP overcomes the inhibitory control of replication during meiosis suggests that this process depends upon protein phosphorylation, while DNA synthesis regulation in mitotic cells relies on 6-DMAP-insensitive events. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:17:49