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Titolo:
ANALYSIS OF CEREBRAL BLOOD-FLOW AUTOREGULATION IN NEONATES
Autore:
PANERAI RB; KELSALL AWR; RENNIE JM; EVANS DH;
Indirizzi:
UNIV LEICESTER,LEICESTER ROYAL INFIRM,DIV MED PHYS LEICESTER LE1 5WW LEICS ENGLAND ROSIE MATERN HOSP CAMBRIDGE CB2 2SW ENGLAND UNIV LONDON KINGS COLL HOSP,CHILDRENS NATIONWIDE NEONATAL UNIT LONDONSE5 9RS ENGLAND
Titolo Testata:
IEEE transactions on biomedical engineering
fascicolo: 8, volume: 43, anno: 1996,
pagine: 779 - 788
SICI:
0018-9294(1996)43:8<779:AOCBAI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
VELOCITY RELATIONSHIPS; CHEMICAL-REGULATION; DOPPLER ULTRASOUND; MATHEMATICAL-MODEL; AUTO-REGULATION; PRESSURE; INFANTS; HUMANS; DYNAMICS; CIRCULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Panerai et al., "ANALYSIS OF CEREBRAL BLOOD-FLOW AUTOREGULATION IN NEONATES", IEEE transactions on biomedical engineering, 43(8), 1996, pp. 779-788

Abstract

The dynamic response of cerebral autoregulation to spontaneous changes in arterial blood pressure (ABP) is described by the relationship between cerebral blood how velocity (CBFV) and resistance-area product (RAP), CBFV was measured with Doppler ultrasound in the middle cerebralartery and ABP with an intra-arterial catheter in 66 neonates, Spontaneous changes in mean ABP were automatically detected and the maximum derivative was used to synchronize the coherent averaging of corresponding CBFV and RAP transients, These were classified into two groups corresponding to intact (group A) or impaired (group B) autoregulation. The cross correlation between RAP and CBFV indicates a significant relationship with a time delay of 5 s for group A, The frequency responseof RAP was estimated by the cross spectra with CBFV, Groups A and B present a similar amplitude spectra but the phase spectra of group A lags that of group B, The impulse responses of the two groups are also markedly different and were used to simulate the velocity response to a5% step change in ABP. Impulse responses were also obtained for four different levels of pCO(2) showing that hypercapnia leads to an impulse response similar to that of group B (impaired autoregulation). This method can be used to extend the usual dichotomic classification adopted in clinical studies of autoregulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:34:58