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Titolo:
NEONATAL CHOLESTASIS AS THE PRESENTING FEATURE IN CYSTIC-FIBROSIS
Autore:
LYKAVIERIS P; BERNARD O; HADCHOUEL M;
Indirizzi:
CHU BICETRE,DEPT PAEDIAT,SERV HEPATOL,78 RUE GEN LECLERC F-94275 LE KREMLIN BICETR FRANCE
Titolo Testata:
Archives of Disease in Childhood
fascicolo: 1, volume: 75, anno: 1996,
pagine: 67 - 70
SICI:
0003-9888(1996)75:1<67:NCATPF>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER;
Keywords:
NEONATAL CHOLESTASIS; CYSTIC FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P. Lykavieris et al., "NEONATAL CHOLESTASIS AS THE PRESENTING FEATURE IN CYSTIC-FIBROSIS", Archives of Disease in Childhood, 75(1), 1996, pp. 67-70

Abstract

Between 1960 and 1994 cystic fibrosis was found in nine out of 1474 infants investigated for neonatal cholestasis. Four had delay in passing meconium. In all patients cholestatic jaundice was present during the first 48 hours and in three patients cholestasis was complete, mimicking biliary atresia. Serum cholesterol concentrations were normal in all but two children. Sweat chloride was repeatedly above 95 mmol/l inall instances. Three children had another condition enhancing the risk of cholestasis (alpha(1)-antitrypsin deficiency, hypopituitarism, perinatal asphyxia, and total parenteral nutrition). Liver histology displayed portal fibrosis and inflammation with bile duct proliferation; mucous plugs in bile ducts were observed in only one patient. Only onechild died from cirrhosis. These results indicate that cystic fibrosis is not a major cause of neonatal cholestasis. However early signs ofintestinal obstruction and low concentrations of serum cholesterol may indicate cystic fibrosis, regardless of liver histology. Neonatal cholestasis has no prognostic value concerning evolution to cirrhosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:14:15