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Titolo:
SEQUENCE VARIABILITY AMONG-DIFFERENT PARVOVIRUS B19 ISOLATES
Autore:
HEMAUER A; VONPOBLOTZKI A; GIGLER A; CASSINOTTI P; SIEGL G; WOLF H; MODROW S;
Indirizzi:
UNIV REGENSBURG,INST MED MIKROBIOL & HYG,FRANZ JOSEF STR ALLEE 11 D-93053 REGENSBURG GERMANY UNIV REGENSBURG,INST MED MIKROBIOL & HYG D-93053 REGENSBURG GERMANY INST KLIN MIKROBIOL & IMMUNOL CH-9001 ST GALLEN SWITZERLAND
Titolo Testata:
Journal of General Virology
, volume: 77, anno: 1996,
parte:, 8
pagine: 1781 - 1785
SICI:
0022-1317(1996)77:<1781:SVAPBI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTRUCTURAL PROTEIN; IMMUNE-RESPONSE; BONE-MARROW; INFECTION; VIRUS; ANTIBODIES; PERSISTENCE; ANEMIA; CRISIS; SERUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
A. Hemauer et al., "SEQUENCE VARIABILITY AMONG-DIFFERENT PARVOVIRUS B19 ISOLATES", Journal of General Virology, 77, 1996, pp. 1781-1785

Abstract

Parvovirus B19 is the causative agent of a variety of clinical manifestations, ranging from asymptomatic to severe infection, The basis forthis complex pattern of B19-associated diseases is as yet poorly understood. In general there are two different possibilities: firstly, theinfected individuals may have a genetic or acquired predisposition, which renders them susceptible for a certain course of infection; secondly, differences in the B19 genome may result in different outcomes ofinfection, In order to investigate this second possibility we have partially sequenced the genomes of 20 different B19 isolates derived from serum samples from patients with various B19-associated diseases. Four distinct regions, which cover nearly half of the genome and includeparts of the coding regions of all three major B19 proteins - NS1, VP1 and VP2, were selected for sequencing. Comparisons between the different extracted virus isolates at the DNA and protein levels revealed that isolates from patients with persistent parvovirus B19 infection show a tendency towards higher genome variability with respect to isolates derived from persons with acute infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:53:41