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Titolo:
PRIMARY CYTOMEGALOVIRUS-INFECTION IN LIVER-TRANSPLANT RECIPIENTS - COMPARISON OF INFECTIONS TRANSMITTED VIA DONOR ORGANS AND VIA TRANSFUSIONS
Autore:
FALAGAS ME; SNYDMAN DR; RUTHAZER R; GRIFFITH J; WERNER BG; ROHRER R; FREEMAN R; FAWAZ K; HOFFMAN MA; KAPLAN M; GILL M; RUBIN RH; DIENSTAG JL; DORAN M; OROURKE E; VACANTI J; JENKINS R; LEWIS D; HAMMER S; MARTIN M; FAIRCHILD R; GRADY GF; LESZCZYNSKI J; DOUGHERTY N; KATZ A; FAUSETT G; PLATT R; CHEESEMAN SH; PASTERNACK M; GORBACH SL;
Indirizzi:
TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED,750 WASHINGTON ST,BOX 238 BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DEPT MED BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DEPT PATHOL BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DEPT SURG BOSTON MA 02111 TUFTS UNIV,SCH MED BOSTON MA 02111
Titolo Testata:
Clinical infectious diseases
fascicolo: 2, volume: 23, anno: 1996,
pagine: 292 - 297
SICI:
1058-4838(1996)23:2<292:PCILR->2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE GLOBULIN; DISEASE; RISK; PREVENTION; PROPHYLAXIS; REJECTION; IMPACT; VIRUS; LOAD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Falagas et al., "PRIMARY CYTOMEGALOVIRUS-INFECTION IN LIVER-TRANSPLANT RECIPIENTS - COMPARISON OF INFECTIONS TRANSMITTED VIA DONOR ORGANS AND VIA TRANSFUSIONS", Clinical infectious diseases, 23(2), 1996, pp. 292-297

Abstract

Primary cytomegalovirus (CMV) infection in liver transplant recipients generally occurs following transmission via a CMV-seropositive donororgan, Occasionally primary infection arises in recipients of CMV-seronegative donor organs through blood transfusions. We studied the differences ia clinical manifestations of primary CMV infection associatedwith these two modes of transmission, among 40 liver transplant recipients who had documented primary CMV infection post-transplantation. Thirty-one of 40 patients received a CMV-seropositive donor organ; CMV infection in the other nine patients was transfusion related. Symptomatic CMV disease (22 of 31 vs. 4 of 9; P = .06), CMV hepatitis (20 of 31 vs. 1 of 9; P = .007), invasive fungal disease (13 of 31 vs, 0 of 9;P = .03), and death (16 of 31 vs. 1 of 9; P = .06) were more likely to occur in patients with donor organ-associated primary CMV infection. The incubation period between transplantation and onset of CMV infection, a possible marker for viral load, was shorter in recipients of donor organ-transmitted CMV infection (median, 44 vs. 137 days; P = .004). Controlling for potential confounders such as immunosuppression didnot alter these associations, Primary CMV infection associated with the donor organ has a more profound impact than primary infection associated with transfusion. These differences may be due to dissimilarities in the viral load associated with donated livers and transfused blood products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:00:10