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Titolo:
THE TEMPORAL-LOBE IS A TARGET OF OUTPUT FROM THE BASAL GANGLIA
Autore:
MIDDLETON FA; STRICK PL;
Indirizzi:
SUNY HLTH SCI CTR,DEPT PHYSIOL SYRACUSE NY 13210 SUNY HLTH SCI CTR,DEPT PHYSIOL SYRACUSE NY 13210 SUNY HLTH SCI CTR,DEPT NEUROSURG SYRACUSE NY 13210 VET ADM MED CTR,RES SERV 151S SYRACUSE NY 13210
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 16, volume: 93, anno: 1996,
pagine: 8683 - 8687
SICI:
0027-8424(1996)93:16<8683:TTIATO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGRA PARS RETICULATA; SUBSTANTIA-NIGRA; TRANSNEURONAL TRANSPORT; SUBCORTICAL CONNECTIONS; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE; THALAMIC NUCLEUS; SQUIRREL-MONKEY; RHESUS-MONKEYS; PROJECTIONS;
Keywords:
INFEROTEMPORAL CORTEX; SUBSTANTIA NIGRA; VIRUS TRANSPORT; CEBUS APELLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
F.A. Middleton e P.L. Strick, "THE TEMPORAL-LOBE IS A TARGET OF OUTPUT FROM THE BASAL GANGLIA", Proceedings of the National Academy of Sciences of the United Statesof America, 93(16), 1996, pp. 8683-8687

Abstract

The basal ganglia are known to receive inputs from widespread regionsof the cerebral cortex, such as the frontal, parietal, and temporal lobes. Of these cortical areas, only the frontal lobe is thought to be the target of basal ganglia output. One of the cortical regions that is a source of input to the basal ganglia is area TE, in inferotemporalcortex. This cortical area is thought to be critically involved in the recognition and discrimination of visual objects. Using retrograde transneuronal transport of herpes simplex 1, we have found that one of the output nuclei of the basal ganglia, the substantia nigra pars reticulata, projects via the thalamus to TE. Thus, TE is not only a sourceof input to the basal ganglia, but also is a target of basal ganglia output. This result implies that the output of the basal ganglia influences higher order aspects of visual processing, In addition, we propose that dysfunction of the basal ganglia loop with TE leads to alterations in visual perception, including visual hallucinations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 09:38:14