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Titolo:
CONTRAST-MEDIA AS EXTRACELLULAR FLUID SPACE MARKERS - ADAPTATION OF THE CENTRAL VOLUME THEOREM
Autore:
DAWSON P; BLOMLEY MJK;
Indirizzi:
HAMMERSMITH HOSP,DEPT DIAGNOST RADIOL,DU CANE RD LONDON W12 0HS ENGLAND ROYAL POSTGRAD MED SCH LONDON W12 0HS ENGLAND
Titolo Testata:
British journal of radiology
fascicolo: 824, volume: 69, anno: 1996,
pagine: 717 - 722
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; CLEARANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
P. Dawson e M.J.K. Blomley, "CONTRAST-MEDIA AS EXTRACELLULAR FLUID SPACE MARKERS - ADAPTATION OF THE CENTRAL VOLUME THEOREM", British journal of radiology, 69(824), 1996, pp. 717-722

Abstract

We present some theoretical observations on the pharmacokinetics of the conventional intravascular radiographic and gadolinium chelate MR contrast agents. These agents may be viewed from a physiological perspective as extracellular fluid (ECF) space markers. It can be shown thatthe passage of such agents through the body may be described by a variant of the ''central volume theorem'', if the central volume is takento be that of the entire extracellular fluid. A consequence is that, in a manner akin to nuclear medicine techniques utilizing technetium-99m diethylene triamine pentacetic acid (DTPA), measures of glomerular filtration rate (GFR) related to total ECF volume rather than to the normal body surface area may be obtained from direct or indirect measurements of iodine or gadolinium plasma levels. Typical measurements arepresented. A simple means is also described of generating curves of the fraction of contrast medium excreted from the body, applicable to both patients with normal and with abnormal renal function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:06:22