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Titolo:
SYNTHESIS OF GROUP-II PHOSPHOLIPASE-A2 AND LYSOZYME IN LACRIMAL GLANDS
Autore:
AHO HJ; SAARI KM; KALLAJOKI M; NEVALAINEN TJ;
Indirizzi:
UNIV TURKU,DEPT PATHOL,KIINAMYLLYNKATU 10 TURKU 20520 FINLAND UNIV TURKU,DEPT OPHTHALMOL TURKU 20520 FINLAND
Titolo Testata:
Investigative ophthalmology & visual science
fascicolo: 9, volume: 37, anno: 1996,
pagine: 1826 - 1832
SICI:
0146-0404(1996)37:9<1826:SOGPAL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC PHOSPHOLIPASE-A2; RIBONUCLEIC-ACID; SYNOVIAL-FLUID; EXPRESSION; ARTHRITIS; TEARS; CELLS;
Keywords:
ANTIINFECTIVE AGENTS; LACRIMAL APPARATUS; LYSOZYME; PHOSPHOLIPASE A2; TEARS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Aho et al., "SYNTHESIS OF GROUP-II PHOSPHOLIPASE-A2 AND LYSOZYME IN LACRIMAL GLANDS", Investigative ophthalmology & visual science, 37(9), 1996, pp. 1826-1832

Abstract

Purpose. The aim of this study was to demonstrate the synthesis and cellular distribution of group IT phospholipase A2 and lysozyme in the main and accessory lacrimal glands. Methods. The authors studied samples of normal main lacrimal glands of seven autopsied subjects and accessory lacrimal glands of eight patients who underwent ptosis surgery. The specimens were immunostained with a rabbit antiserum against groupII phospholipase A2 and a monoclonal antibody against lysozyme. Expression of group II phospholipase A2 gene was shown using Northern hybridization and in situ hybridization. Results. Lysozyme was present in the secretory granules of most acini, whereas group IT phospholipase A2was seen in a minority of acinar cells, primarily in the central parts of lobules in the main and accessory lacrimal glands. Synthesis of group II phospholipase A2 in the glandular cells was confirmed by Northern hybridization and by in situ hybridization. Conclusions. There aretwo specialized cell types in the main and accessary lacrimal glands,one synthesizing group II phospholipase A2 and the other synthesizinglysozyme. These enzymes are important nonspecific antibacterial factors in tears.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:22:12