Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE EFFECTIVENESS OF 2 CIPROFLOXACIN FORMULATIONS FOR EXPERIMENTAL PSEUDOMONAS AND STAPHYLOCOCCUS-KERATITIS
Autore:
ENGEL LS; CALLEGAN MC; HILL JM; FOLKENS AT; SHIMOMURA Y; OCALLAGHAN RJ;
Indirizzi:
LOUISIANA STATE UNIV,CTR EYE,2020 GRAVIER ST,SUITE B NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,CTR EYE NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,SCH MED,DEPT MICROBIOL IMMUNOL & PARASITOL NEW ORLEANS LA 70112 ALCON LABS INC FT WORTH TX 76101 OSAKA UNIV,SCH MED,DEPT OPHTHALMOL SUITA OSAKA 565 JAPAN
Titolo Testata:
Japanese Journal of Ophthalmology
fascicolo: 2, volume: 40, anno: 1996,
pagine: 212 - 219
SICI:
0021-5155(1996)40:2<212:TEO2CF>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZALKONIUM CHLORIDE; TOPICAL CIPROFLOXACIN; ANTIBIOTIC-THERAPY; PRESERVATIVES; TOBRAMYCIN; RABBIT; SUSCEPTIBILITY; IONTOPHORESIS; VEHICLES; HUMANS;
Keywords:
CILOXAN(R); CIPROFLOXACIN-PSS; KERATITIS PSEUDOMONAS; RABBITS; STAPHYLOCOCCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
L.S. Engel et al., "THE EFFECTIVENESS OF 2 CIPROFLOXACIN FORMULATIONS FOR EXPERIMENTAL PSEUDOMONAS AND STAPHYLOCOCCUS-KERATITIS", Japanese Journal of Ophthalmology, 40(2), 1996, pp. 212-219

Abstract

Ciprofloxacin is a fluoroquinolone antibiotic with broad spectrum bactericidal activity. A commercially available form of ciprofloxacin contains benzalkonium chloride (BAC) (0.006%) and EDTA (0.05%) as preservatives. Since BAG has been shown to cause adverse changes in corneal epithelial cells, a formulation of ciprofloxacin devoid of BAC and EDTAbut with the same effectiveness would be valuable. We present here the results of experiments designed to assess the efficacy of a BAC-freeand EDTA-free formulation of ciprofloxacin, Ciprofloxacin-polystyrenesulfonate (PSS), in experimental models of Pseudomonas aeruginosa andStaphylococcus aureas keratitis, Both formulations of ciprofloxacin sterilized corneas infected with P aeruginosa, and both formulations showed equal bactericidal activity for S aureus, Normal eyes treated with either formulation showed mild conjunctival irritation compared to untreated normal eyes. The bactericidal activities of both formulationsof ciprofloxacin were excellent, Therefore, the Ciprofloxacin-PSS formulation could serve as an effective single drug therapy for ocular infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:31:37