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Titolo:
THE EFFECTS OF 5-HYDROXYDOPAMINE ON SALIVARY FLOW-RATES AND PROTEIN SECRETION BY THE SUBMANDIBULAR AND PAROTID-GLANDS OF RATS
Autore:
ABE K; ITOH T; TASHIRO M; OKINA A; GAO C; NAKAMURA H; NOSE T; INOUE H; YU SF;
Indirizzi:
FUKUOKA DENT COLL,DEPT ORAL BIOCHEM FUKUOKA 81401 JAPAN BEIJING MED UNIV,SCH STOMATOL BEIJING 100083 PEOPLES R CHINA FUKUOKA DENT COLL,DEPT ORTHODONT FUKUOKA 81401 JAPAN FUKUOKA DENT COLL,DEPT CONSERVAT DENT FUKUOKA 81401 JAPAN FUKUOKA DENT COLL,DEPT ORAL PATHOL FUKUOKA 81401 JAPAN
Titolo Testata:
Experimental physiology
fascicolo: 4, volume: 81, anno: 1996,
pagine: 645 - 653
SICI:
0958-0670(1996)81:4<645:TEO5OS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-METHYLNORADRENALINE; ELECTROLYTES; NOREPINEPHRINE; TRANSDUCTION; STIMULATION; OCTOPAMINE; RESPONSES; CLONIDINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
K. Abe et al., "THE EFFECTS OF 5-HYDROXYDOPAMINE ON SALIVARY FLOW-RATES AND PROTEIN SECRETION BY THE SUBMANDIBULAR AND PAROTID-GLANDS OF RATS", Experimental physiology, 81(4), 1996, pp. 645-653

Abstract

The secretory effects of 5-hydroxydopamine (5-OHDA) were tested in Nembutal-anaesthetized adult male Sprague-Dawley rats injected I.V. overa wide range of doses, with and without various autonomic antagonistsand Ca2+ channel blockers. Polyacrylamide disc gel (15 %) and iso-electric focusing (IEF) electrophoresis by the PhastSystem were used to separate and determine the types of protein in submandibular saliva. Amylase activity of parotid saliva was determined by the blue dextran method. Salivation by the submandibular glands following application of 5-OHDA was completely abolished by both prazosin and propranolol, whereas salivation by the parotid glands was completely abolished by propranolol alone. Following application of 5-OHDA, there was a dose-related increase in flow rates and total output of protein, but not in the protein concentration and amylase activity, from both salivary glands. The effect of 5-OHDA on submandibular saliva was significantly reducedby alpha-adrenoceptor blockers, but not by beta-adrenoceptor and cholinergic blockers, nor by any Ca2+ channel blocker. The effect of 5-OHDA on the parotid gland was not significantly altered by atropine and phentolamine. However, after pretreatment with reserpine, a 95 % reduction was observed in the salivation from the submandibular gland. This implies that 5-OHDA is mostly acting indirectly via release of noradrenaline. The proteins in submandibular saliva following treatment with 5-OHDA alone or 5-OHDA in combination with beta-adrenoceptor blockers were mainly of the alpha-type, whereas after treatment with 5-OHDA in combination with alpha-adrenoceptor blockers they were of the beta-type. The alpha-type was found in saliva after treatment with each of three Ca2+ channel blockers.

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Documento generato il 03/12/20 alle ore 15:38:13