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Titolo:
ANALYSIS OF RED-BLOOD-CELL MOTION THROUGH CYLINDRICAL MICROPORES - EFFECTS OF CELL PROPERTIES
Autore:
SECOMB TW; HSU R;
Indirizzi:
UNIV ARIZONA,DEPT PHYSIOL TUCSON AZ 85724
Titolo Testata:
Biophysical journal
fascicolo: 2, volume: 71, anno: 1996,
pagine: 1095 - 1101
SICI:
0006-3495(1996)71:2<1095:AORMTC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NARROW PORES; IN-VIVO; FLOW; CAPILLARIES; FILTERABILITY; PASSAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
T.W. Secomb e R. Hsu, "ANALYSIS OF RED-BLOOD-CELL MOTION THROUGH CYLINDRICAL MICROPORES - EFFECTS OF CELL PROPERTIES", Biophysical journal, 71(2), 1996, pp. 1095-1101

Abstract

Filtration through micropores is frequently used to assess red blood cell deformability, but the dependence of pore transit time on cell properties is not well understood. A theoretical model is used to simulate red cell motion through cylindrical micropores with diameters of 3.6, 5, and 6.3 mu m, and 11-mu m length, at driving pressures of 100-1000 dyn/cm(2). Cells are assumed to have axial symmetry and to conservesurface area during deformation. Effects of membrane shear viscosity and elasticity are included, but bending resistance is neglected, A time-dependent lubrication equation describing the motion of the suspending fluid is solved, together with the equations for membrane equilibrium, using a finite difference method. Predicted transit times are consistent with previous experimental observations. Time taken for cells to enter pores represents more than one-half of the transit time. Predicted transit lime increases with increasing membrane viscosity and with increasing cell volume. it is relatively insensitive to changes in internal viscosity and to changes in membrane elasticity except in thenarrowest pores at low driving pressures. Elevating suspending mediumviscosity does not increase sensitivity of transit time to membrane properties. Thus filterability of red cells is sensitively dependent ontheir resistance to transient deformations, which may be a key determinant of resistance to blood flow in the microcirculation.

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Documento generato il 28/09/20 alle ore 19:58:38