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Titolo:
INFLUENCE OF NICARDIPINE, NIMODIPINE AND FLUNARIZINE ON THE ANTICONVULSANT EFFICACY OF ANTIEPILEPTICS AGAINST PENTYLENETETRAZOL IN MICE
Autore:
GASIOR M; KAMINSKI R; BRUDNIAK T; KLEINROK Z; CZUCZWAR SJ;
Indirizzi:
LUBLIN MED UNIV SCH,DEPT PHARMACOL & TOXICOL,JACZEWSKIEGO 8 PL-20090 LUBLIN POLAND LUBLIN MED UNIV SCH,DEPT PHARMACOL & TOXICOL PL-20090 LUBLIN POLAND
Titolo Testata:
Journal of neural transmission
fascicolo: 7, volume: 103, anno: 1996,
pagine: 819 - 831
SICI:
0300-9564(1996)103:7<819:IONNAF>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-CHANNEL INHIBITORS; ADD-ON THERAPY; CEREBRAL-CORTEX; RAT-BRAIN; EPILEPSY; DRUGS; MECHANISMS; SEIZURES; SYNAPTOSOMES; CONVULSIONS;
Keywords:
ANTIEPILEPTICS; FLUNARIZINE; NICARDIPINE; NIMODIPINE; CALCIUM CHANNEL INHIBITORS; PENTYLENETETRAZOL; SEIZURES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
M. Gasior et al., "INFLUENCE OF NICARDIPINE, NIMODIPINE AND FLUNARIZINE ON THE ANTICONVULSANT EFFICACY OF ANTIEPILEPTICS AGAINST PENTYLENETETRAZOL IN MICE", Journal of neural transmission, 103(7), 1996, pp. 819-831

Abstract

Among three calcium channel inhibitors, only nicardipine (10-40 mg/kg) significantly inhibited clonic seizures induced by pentylenetetrazoladministered at its CD97 (convulsive dose 97%) of 81 mg/kg, subcutaneously. Nimodipine and flunarizine (both up to 80 mg/kg) did not suppress pentylenetetrazol-induced clonic seizures per se. Co-administrationof nicardipine (5 mg/kg) resulted in a significant enhancement of theprotective potency of either ethosuximide (50 mg/kg) or valproate (100 mg/kg) against clonic seizures in this test. Similar effects were noted in case of combined treatment of nimodipine (20-40 mg/kg) with these antiepileptics. On the contrary: flunarizine (up to 20 mg/kg) did not modify the anticonvulsive action of these antiepileptic drugs. Moreover, none of the studied calcium channel inhibitors influenced the protective activity of clonazepam (0.01 mg/kg). The antiepileptic drugs,administered alone in above doses, were ineffective against pentylenetetrazol-induced clonic convulsions. In case of ethosuximide and valproate, the motor performance in the chimney test was worsened by co-administration of nimodipine (40 mg/kg). We found no pharmacokinetic interactions (at least in relation to the plasma levels of ethosuximide and valproate) that could explain the observed results. Thus. we conclude that a combination of some calcium channel inhibitors and antiepileptic drugs may provide more efficient protection against experimental seizures which may bear a potential clinical significance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 17:43:35