Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
OX40 IS DIFFERENTIALLY EXPRESSED ON ACTIVATED RAT AND MOUSE T-CELLS AND IS THE SOLE RECEPTOR FOR THE OX40 LIGAND
Autore:
ALSHAMKHANI A; BIRKELAND ML; PUKLAVEC M; BROWN MH; JAMES W; BARCLAY AN;
Indirizzi:
UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,MRC,CELLULAR IMMUNOL UNIT OXFORD OX1 3RE ENGLAND UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,MRC,CELLULAR IMMUNOL UNIT OXFORD OX1 3RE ENGLAND
Titolo Testata:
European Journal of Immunology
fascicolo: 8, volume: 26, anno: 1996,
pagine: 1695 - 1699
SICI:
0014-2980(1996)26:8<1695:OIDEOA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR RECEPTOR; GROWTH-FACTOR RECEPTOR; MOLECULAR-CLONING; KINETIC-ANALYSIS; LYMPHOCYTES-T; SOLUBLE FORM; ANTIGEN; FAMILY; MEMBER; CDNA;
Keywords:
OX40; OX40 LIGAND; T CELL ACTIVATION; TUMOR NECROSIS FACTOR RECEPTOR NERVE GROWTH FACTOR RECEPTOR SUPERFAMILY MRC OX86; MONOCLONAL ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Alshamkhani et al., "OX40 IS DIFFERENTIALLY EXPRESSED ON ACTIVATED RAT AND MOUSE T-CELLS AND IS THE SOLE RECEPTOR FOR THE OX40 LIGAND", European Journal of Immunology, 26(8), 1996, pp. 1695-1699

Abstract

OX40, a member of the tumor necrosis factor (TNF) receptor/nerve growth factor (NGF) receptor superfamily was first identified as a marker of activated rat CD4(+) cells with the MRC OX40 monoclonal antibody (mAb). A ligand for OX40 (called OX40 ligand or OX40L) has recently beenidentified and has sequence similarity to TNF. Mouse OX40L-immunoglobulin fusion protein (OX40L-Ig) binds to activated mouse CD4(+) and CD8(+) cells (Baum, P. R, et al., EMBO J. 1994. 13: 3992) suggesting thatOX40 could have a differential pattern of expression on mouse and ratT cells. This, however, did not rule out the presence of an alternative receptor on CD8(+) cells that also binds the OX40L. We have compared the binding of the MRC OX40 mAb with that of OX40L-Ig to activated rat lymph node cells and show that both recognize the same protein, namely OX40 which is expressed on CD4(+) and CD4(+) CD8 alpha(+) cells, but not on CD4(-) CD8(+) cells. We have raised a new mAb (MRC OX86) using recombinant mouse OX40 protein and show by two-color flow cytometrythat mouse OX40 is expressed on CD4 and CD8 single-positive cells. Inaddition, the new MRC OX86 mAb, unlike the MRC OX40 mAb, did not block binding of the OX40L. We conclude that OX40 is differentially expressed on activated mouse and rat T cells and is the sole receptor for the OX40L.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 09:02:26