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Titolo:
TRANSCRIPTION OF C-MOS PROTOONCOGENE IN THE PIG INVOLVES BOTH TISSUE-SPECIFIC PROMOTERS AND ALTERNATIVE POLYADENYLATION SITES
Autore:
NEWMAN B; DAI YF;
Indirizzi:
BABRAHAM INST,LAB DEV & DIFFERENTIAT,DEPT DEV & SIGNALLING CAMBRIDGE CB2 4AT ENGLAND
Titolo Testata:
Molecular reproduction and development
fascicolo: 3, volume: 44, anno: 1996,
pagine: 275 - 288
SICI:
1040-452X(1996)44:3<275:TOCPIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTO-ONCOGENE PRODUCT; SHORT SEQUENCE ELEMENT; METAPHASE-II ARREST; MESSENGER-RNA; CYTOPLASMIC POLYADENYLATION; TRANSLATIONAL CONTROL; MEIOTIC MATURATION; OOCYTE MATURATION; MOUSE OOCYTES; PARTHENOGENETIC DEVELOPMENT;
Keywords:
MATERNAL MESSENGER-RNA; TRANSLATIONAL CONTROL; MEIOTIC MATURATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
B. Newman e Y.F. Dai, "TRANSCRIPTION OF C-MOS PROTOONCOGENE IN THE PIG INVOLVES BOTH TISSUE-SPECIFIC PROMOTERS AND ALTERNATIVE POLYADENYLATION SITES", Molecular reproduction and development, 44(3), 1996, pp. 275-288

Abstract

The function of the c-mos gene has been intensively studied, but its role in the mammal is still a subject for debate. For this reason, andbecause the gene is regulated posttranscriptionally, further study ofthe gene from other mammalian species is timely. The pig c-mos gene has been cloned, and the genomic sequence is presented here. The gene has no introns and shows close similarity to human and monkey genes, with striking sequence similarities in both the 5' and 3' flanking regions. The significance of this similarity in the context of gene regulation is discussed. c-mos expression was found to be restricted to gonadal tissues in the pig. The major start sites for transcription initiation in ovary and testis were identified by primer extension and found to be distinct, as in the mouse. Within the ovary, expression is confined to oocytes. Messenger RNA is synthesized in growing oocytes, and remains stable during oocyte maturation, but begins to be degraded in electrically stimulated eggs. Unexpectedly, RNase protection assays revealed that the 3' ends of transcripts in the pig ovary are heterogeneous, and this, together with the identification of three distinct cDNA clones, shows that multiple polyadenylation sites are used. The significance of these transcripts in terms of translational control is discussed. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 10:27:57