Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
QUANTIFICATION OF MRI LESION LOAD IN MULTIPLE-SCLEROSIS - A COMPARISON OF 3 COMPUTER-ASSISTED TECHNIQUES
Autore:
GRIMAUD J; LAI M; THORPE J; ADELEINE P; WANG L; BARKER GJ; PLUMMER DL; TOFTS PS; MCDONALD WI; MILLER DH;
Indirizzi:
UNIV LONDON,INST NEUROL,DEPT CLIN NEUROL,QUEEN SQ LONDON WC1N 3BG ENGLAND NATL HOSP NEUROL & NEUROSURG,INST NEUROL,NMR RES UNIT LONDON WC1N 3BGENGLAND
Titolo Testata:
Magnetic resonance imaging
fascicolo: 5, volume: 14, anno: 1996,
pagine: 495 - 505
SICI:
0730-725X(1996)14:5<495:QOMLLI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATTENUATED INVERSION-RECOVERY; FLAIR PULSE SEQUENCES; INTERFERON THERAPY; BRAIN; SEGMENTATION; DISABILITY; IMAGES;
Keywords:
MULTIPLE SCLEROSIS; BRAIN MAGNETIC RESONANCE IMAGING; LESION VOLUME MEASUREMENT; PRECISION; REPEATABILITY; REPRODUCIBILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Grimaud et al., "QUANTIFICATION OF MRI LESION LOAD IN MULTIPLE-SCLEROSIS - A COMPARISON OF 3 COMPUTER-ASSISTED TECHNIQUES", Magnetic resonance imaging, 14(5), 1996, pp. 495-505

Abstract

Several computer-assisted techniques for measuring multiple sclerosislesion load on MR images have been developed to provide a quantitative and sensitive means for monitoring disease activity, particularly inthe context of treatment trials. We have evaluated three techniques: manual outlining (similar to that of the North American interferon beta-lb trial), semiautomated lesion contouring (local lesion based threshold), and intensity-based thresholding for the whole brain. Contiguous, 5 mm-thick, axial, T-2-weighted images of the brain were obtained on a 1.5T MR imager in eight patients with clinically definite multiplesclerosis. Analyses of the scans were performed twice, independently by three operators, using the three different techniques. The coefficient of variation of the measurement techniques was: (a) intrarater precision, 9.0 +/- 5.2 (mean +/- SD) (range 0.4-18.5) for the manual outlining, 2.5 +/- 2.1 (0.1-7.7) for the contour technique, and 7.5 +/- 6.9 (0.2-22.0) for the global threshold technique; (b) interrater precision, 11.0 +/- 5.8 (4.9-21.7) for the manual outlining, 4.5 +/- 1.6 (1.8-6.6) for the contour technique, and 11.4 +/- 4.9 (2.8-19.2) for the global threshold technique (0.0 = perfect precision). The absolute lesion loads measured were very similar using the manual outlining and the contour techniques but were significantly smaller using the global threshold technique. We conclude that the contour technique is a promising tool for use in treatment trials. Further studies are needed to assess sensitivity to changes in lesion load over time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 20:57:05