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Titolo:
HYPOCOMPLEMENTEMIA AND HEMATOLOGICAL ABNORMALITIES IN IMMUNOBLASTIC LYMPHADENOPATHY AND IMMUNOBLASTIC LYMPHADENOPATHY-LIKE T-CELL LYMPHOMA
Autore:
HIGUCHI T; MORI H; NIIKURA H; OMINE M;
Indirizzi:
1-30 FUJIGAOKA,AOBA KU YOKOHAMA KANAGAWA 227 JAPAN SHOWA UNIV,FUJIGAOKA HOSP,DIV HEMATOL YOKOHAMA KANAGAWA 227 JAPAN
Titolo Testata:
Acta haematologica
fascicolo: 2, volume: 96, anno: 1996,
pagine: 68 - 72
SICI:
0001-5792(1996)96:2<68:HAHAII>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED AUTOIMMUNE THROMBOCYTOPENIA; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY; APLASIA; DYSPROTEINEMIA; VASCULITIS; ANTIBODIES; EVOLUTION; SPECTRUM; DISEASE;
Keywords:
ANEMIA; AUTOIMMUNITY; COMPLEMENT; IMMUNOBLASTIC LYMPHADENOPATHY; THROMBOCYTOPENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Higuchi et al., "HYPOCOMPLEMENTEMIA AND HEMATOLOGICAL ABNORMALITIES IN IMMUNOBLASTIC LYMPHADENOPATHY AND IMMUNOBLASTIC LYMPHADENOPATHY-LIKE T-CELL LYMPHOMA", Acta haematologica, 96(2), 1996, pp. 68-72

Abstract

Serum complement levels and hematological data were evaluated in fivepatients with immunoblastic lymphadenopathy (IBL) and four with IBL-like T cell lymphoma (IBL-T). Anemia with Hb values below 10.0 g/dl wasseen in four patients. A direct Coombs test was positive in five patients and the bone marrow of two of these showed features of pure red cell aplasia. Seven patients were thrombocytopenic with platelet countsbelow 100 x 10(9)/1. Six of the seven patients had splenomegaly. Platelet-associated IgG was elevated in all three thrombocytopenic patients examined. Whole complement activity (CH50) was reduced in eight patients (89%) at presentation and subsequently normalized in five who were treated either with prednisolone (two patients with IBL) or with multidrug combination chemotherapy (three with IBL-T). One patient achieved complete remission and four partial remission. Remission was accompanied by normalization of hematological abnormalities and elevation ofcomplement activity to the normal range in all cases. These results suggested that complement-mediated mechanisms are responsible, at leastin part, for some of the hematological abnormalities observed in IBL and IBL-T and that hypocomplementemia is a common abnormality with significance as a laboratory marker for the disease activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:50:02