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Titolo:
MULTIPLE ACTIONS OF 1S,3R-ACPD IN MODULATING ENDOGENOUS SYNAPTIC TRANSMISSION TO SPINAL RESPIRATORY MOTONEURONS
Autore:
DONG XW; MORIN D; FELDMAN JL;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PHYSIOL,SYST NEUROBIOL LAB,POB 951527 LOSANGELES CA 90095 UNIV CALIF LOS ANGELES,DEPT NEUROBIOL LOS ANGELES CA 90095
Titolo Testata:
The Journal of neuroscience
fascicolo: 16, volume: 16, anno: 1996,
pagine: 4971 - 4982
SICI:
0270-6474(1996)16:16<4971:MAO1IM>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
METABOTROPIC GLUTAMATE-RECEPTOR; INHIBITS CALCIUM CURRENTS; NEONATAL RAT HIPPOCAMPUS; CENTRAL-NERVOUS-SYSTEM; PHRENIC MOTONEURONS; MOLECULAR CHARACTERIZATION; SIGNAL-TRANSDUCTION; INSPIRATORY DRIVE; PHARMACOLOGICAL PROPERTIES; STRIATAL NEURONS;
Keywords:
1S,3R-ACPD; METABOTROPIC GLUTAMATE RECEPTORS; SYNAPTIC TRANSMISSION; PRESYNAPTIC; EXCITABILITY; POTASSIUM CHANNELS; BRAIN-STEM; SPINAL CORD; PHRENIC MOTONEURONS; RESPIRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
X.W. Dong et al., "MULTIPLE ACTIONS OF 1S,3R-ACPD IN MODULATING ENDOGENOUS SYNAPTIC TRANSMISSION TO SPINAL RESPIRATORY MOTONEURONS", The Journal of neuroscience, 16(16), 1996, pp. 4971-4982

Abstract

To determine physiological roles of metabotropic glutamate receptors (mGluRs) affecting breathing, we examined the effects of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) on synaptic transmission and excitability of phrenic motoneurons (PMNs) in an in vitro neonatal rat brainstem/spinal cord preparation. The effects of 1S,3R-ACPDwere multiple, including reduction of inspiratory-modulated synaptic currents and increase of neuronal excitability via an inward current (I-acpd) associated with a decrease of membrane conductance. The mechanism underlying synaptic depression was examined. We found that IS,3R-ACPD reduced the frequency but not the amplitude of miniature excitatory postsynaptic currents, The current induced by exogenous AMPA was notsignificantly affected by 1S,3R-ACPD. These results suggest that 1S,3R-ACPD-induced reduction of inspiratory synaptic currents is mediated by presynaptic mGluRs. We also examined the ionic basis for I-acpd. Wefound that I-acpd had a reversal potential of approximately -100 mV, close to the estimated E(K+) (-95 mV). Elevating extracellular [K+] to9 mM reduced the I-acpd reversal potential to -75 mV. The K+ channel blocker Ba2+ induced an inward current with a reversal potential at -93 mV associated with a decrease of membrane conductance, closely resembling the effect of 1S,3R-ACPD. Moreover, Ba2+ occluded 1S,3R-ACPD effects. In the presence of Ba2+, I-acpd and the 1S,3R-ACPD-induced decrease of membrane conductance were diminished. Our data indicate that the dominant component of I-acpd results from the blockade of a Ba2+-sensitive resting K+ conductance. We conclude that the activation of mGluRs affects the inspiratory-modulated activity of PMNs via distinct mechanisms at pre- and postsynaptic sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 11:41:49