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Titolo:
CHANGES IN THE ELECTRICAL-PROPERTIES OF SUPRAOPTIC NUCLEUS OXYTOCIN AND VASOPRESSIN NEURONS DURING LACTATION
Autore:
STERN JE; ARMSTRONG WE;
Indirizzi:
UNIV TENNESSEE,COLL MED,DEPT ANAT & NEUROBIOL,855 MONROE AVE MEMPHIS TN 38163
Titolo Testata:
The Journal of neuroscience
fascicolo: 16, volume: 16, anno: 1996,
pagine: 4861 - 4871
SICI:
0270-6474(1996)16:16<4861:CITEOS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MILK-EJECTION REFLEX; MAMMALIAN NEUROENDOCRINE CELLS; NEUROSECRETORY NEURONS; ELECTROPHYSIOLOGICAL CHARACTERISTICS; POTASSIUM CURRENTS; SECRETING NEURONS; ACTION-POTENTIALS; RECORDED INVITRO; IN-VITRO; RAT;
Keywords:
ELECTROPHYSIOLOGY; OXYTOCIN; VASOPRESSIN; LACTATION; SUPRAOPTIC NUCLEUS; MAGNOCELLULAR CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Stern e W.E. Armstrong, "CHANGES IN THE ELECTRICAL-PROPERTIES OF SUPRAOPTIC NUCLEUS OXYTOCIN AND VASOPRESSIN NEURONS DURING LACTATION", The Journal of neuroscience, 16(16), 1996, pp. 4861-4871

Abstract

Magnocellular oxytocin (OT) and vasopressin (VP) neurons adopt different firing patterns in response to relevant physiological stimuli. OT neurons selectively display short (2-4 sec), high-frequency bursts of action potentials that are highly synchronized and correlated with OT release during lactation. The present experiments were done to determine whether the electrophysiological properties of OT neurons differ from those of VP neurons, and whether these properties are modulated during lactation to support short bursting activity. Intracellular recordings in vitro were obtained from immunochemically identified supraoptic neurons of diestrous or lactating female rats. Resting membrane potential, input resistance, membrane time constant, and the depolarizing afterpotential did not differ among groups. However, near spike threshold, OT, but not VP, neurons expressed a sustained outward rectification that was removed by small hyperpolarizing pulses and a rebound depolarization that occurred at the offset of these hyperpolarizing pulses. The rebound depolarization was short (<2 sec), supported brief bursts of action potentials, and was significantly larger during lactation. Neurons expressing the outward rectification also exhibited strong spike frequency adaptation during prolonged (1-4 sec) depolarization. Spike width, the Ca2+-dependent afterhyperpolarization, and the degree of spike broadening of OT, but not VP, neurons were also larger during lactation, suggesting an increase in Ca2+ influx per spike. The results indicate that OT neurons possess properties favoring the expression of short spike trains, and that some of these properties are enhanced during lactation. In addition, spikes in OT neurons may promote more Ca2+ influx in this state.

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Documento generato il 03/07/20 alle ore 01:46:29