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Titolo:
SENSITIZATION INDUCED BY KINDLING AND KINDLING-RELATED PHENOMENA AS AMODEL FOR MULTIPLE CHEMICAL-SENSITIVITY
Autore:
ROSSI J;
Indirizzi:
USAF,MED RES INST DETACHMENT TOXICOL,TRI SERV TOXICOL CONSORTIUM,26125TH ST,AREA B WRIGHT PATTERSON AFB OH 45433
Titolo Testata:
Toxicology
fascicolo: 1-3, volume: 111, anno: 1996,
pagine: 87 - 100
SICI:
0300-483X(1996)111:1-3<87:SIBKAK>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; TIME-DEPENDENT SENSITIZATION; RABBIT FOLLOWING STIMULATION; PERFORANT PATH; BENZODIAZEPINE RECEPTOR; ELECTRICAL-STIMULATION; SYNAPTIC TRANSMISSION; LASTING POTENTIATION; HIPPOCAMPAL SLICE; SEIZURE ACTIVITY;
Keywords:
MULTIPLE CHEMICAL SENSITIVITY (MCS); KINDLING; NEURAL SENSITIZATION; BEHAVIORAL SENSITIZATION; NEURAL POTENTIATION; ANIMAL MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
J. Rossi, "SENSITIZATION INDUCED BY KINDLING AND KINDLING-RELATED PHENOMENA AS AMODEL FOR MULTIPLE CHEMICAL-SENSITIVITY", Toxicology, 111(1-3), 1996, pp. 87-100

Abstract

It has been suggested that the neurobehavioral dysfunction observed in persons presenting with symptoms of Multiple Chemical Sensitivity (MCS) syndrome involves sensitization of neural circuits. Two hypothesesfor the route of exposure in induction of neural sensitization in MCSare: (a) direct chemical stimulation of olfactory processes, or (b) general systemic response to inhaled chemicals. In either case, the mechanism of action may involve chemical kindling or kindling-related phenomena. A neural sensitization mechanism based on kindling or kindling-related phenomena is attractive and has been previously demonstrated in both in vitro and in vivo animal models. Without a testable animal model for chemically mediated induction of MCS, however, any argument that MCS is mediated by kindling or kindling-related phenomena is reduced to the circular argument ''the mechanism of sensitization is sensitization. '' The present survey provides an overview of the experimental paradigms that result in sensitization, differentiated on the basis of probable neurophysiological and neurochemical mechanisms. Neurophysiological potentiation, electrical kindling, chemical kindling and behavioral sensitization are evaluated and discussed in relationship to MCS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 02:53:06