Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEUROTROPHIC FACTORS IN PERIPHERAL NEUROPATHIES - PHARMACOLOGICAL STRATEGIES
Autore:
RIAZ SS; TOMLINSON DR;
Indirizzi:
UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL,MILE END RD LONDON E1 4NS ENGLAND UNIV LONDON QUEEN MARY & WESTFIELD COLL,DEPT PHARMACOL LONDON E1 4NS ENGLAND
Titolo Testata:
Progress in neurobiology
fascicolo: 2, volume: 49, anno: 1996,
pagine: 125 - 143
SICI:
0301-0082(1996)49:2<125:NFIPN->2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; FACTOR MESSENGER-RNA; FACTOR SYNTHESIS SECRETION; MOUSE ASTROGLIAL CELLS; SLOW AXONAL-TRANSPORT; BETA-ADRENERGIC-RECEPTOR; EXPERIMENTAL DIABETIC NEUROPATHY; TRK PROTOONCOGENE PRODUCT; RAT SCIATIC-NERVE; PROTEIN-KINASE-C;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
171
Recensione:
Indirizzi per estratti:
Citazione:
S.S. Riaz e D.R. Tomlinson, "NEUROTROPHIC FACTORS IN PERIPHERAL NEUROPATHIES - PHARMACOLOGICAL STRATEGIES", Progress in neurobiology, 49(2), 1996, pp. 125-143

Abstract

Peripheral neuropathy is defined as a derangement in structure and function of peripheral motor, sensory and autonomic neurones, and can involve either the entire neurone or selected parts of the neurone. Due to the complex and diverse nature of the neurone, there are many potential sites and mechanisms Which can be influenced to provoke a dysfunctional state. The cellular and molecular mechanisms involved in the development of neuropathy are therefore diverse and only partially understood, Studies have been undertaken using many drugs and disease models to cause pathological insult to the nervous system resulting in experimental neuropathies. To some extent it is possible to correlate the locality of the pathological insult within the neurone to the type of neuropathy manifested. Nerve growth factor belongs to a family of neurotrophins implicated in the survival of many different types of neurones. Hence in the deranged nerve it could be envisaged that the there is a reduction in either the availability of NGF to the neurone or an impairment in the machinery transducing its response. One mechanism therefore would be the introduction of compounds into the system that cause the induction of NGF. To this end many compounds are under investigation in culture and in animals models to ascertain their effect on NGF with the view that such drugs can then be extrapolated to the human pathological condition, This review will describe the current state ofresearch into the compounds that induce NGF, whilst recognising that the effects of NGF are selective for certain classes of neurone, but that similar mechanisms may operate for other neurotrophic factors witheffects on a wider population of nerves. Copyright (C) 1996 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:08:40