Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MAJOR PHARMACOLOGICAL DISTINCTION OF THE ACTH RECEPTOR FROM OTHER MELANOCORTIN RECEPTORS
Autore:
SCHIOTH HB; CHHAJLANI V; MUCENIECE R; KLUSA V; WIKBERG JES;
Indirizzi:
BIOMED CTR,BOX 591 S-75124 UPPSALA SWEDEN UPPSALA UNIV,DEPT PHARMACEUT PHARMACOL UPPSALA SWEDEN LATVIAN ACAD SCI,INST ORGAN SYNTH,PHARMACOL LAB LV-226006 RIGA LATVIA WA PHARM UMEA SWEDEN
Titolo Testata:
Life sciences
fascicolo: 10, volume: 59, anno: 1996,
pagine: 797 - 801
SICI:
0024-3205(1996)59:10<797:MPDOTA>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; MOLECULAR-CLONING; ADRENOCORTICAL-CELLS; MESSENGER-RNA; EXPRESSION; CORTICOTROPIN; BINDING; MOUSE; CDNA; GENE;
Keywords:
MELANOCORTIN RECEPTOR SUBTYPES; [I-125] [NLE(4), D-PHE(7)]ALPHA-MSH LIGAND BINDING; ACTH; Y1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
H.B. Schioth et al., "MAJOR PHARMACOLOGICAL DISTINCTION OF THE ACTH RECEPTOR FROM OTHER MELANOCORTIN RECEPTORS", Life sciences, 59(10), 1996, pp. 797-801

Abstract

The mouse adrenocortical cell line Y1, that expresses ACTH receptors (MC2R), was used to probe the binding of ACTH and MSH peptides by using radio-labelled ACTH (1-39). The Y1 cells were found to bind [I-125]-labelled ACTH(1-39) with high affinity (K-d similar to 130 pM). However, none of the melanocortin peptides NDP-MSH, alpha-MSH, beta-MSH or gamma 1-MSH could compete with the binding of the labelled ACTH(1-39). When other MC receptor subtype DNAs (MC1, MC3 and MC4) were transfected into the Y1 cells, characteristic binding of the [I-125]NDP-MSH appeared for each of the receptor subtype, but no specific binding was present in non-transfected cells. This is the first report clearly demonstrating that the ACTH receptor binds only ACTH, but not other melanocortin peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:56:52