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Titolo:
CHOLECYSTOKININ DEPOLARIZES NEURONS OF CAT PANCREATIC GANGLION
Autore:
MA RC; SZURSZEWSKI JH;
Indirizzi:
MAYO CLIN & MAYO FDN,DEPT PHYSIOL & BIOPHYS ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT PHYSIOL & BIOPHYS ROCHESTER MN 55905
Titolo Testata:
Peptides
fascicolo: 5, volume: 17, anno: 1996,
pagine: 775 - 783
SICI:
0196-9781(1996)17:5<775:CDNOCP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFERIOR MESENTERIC GANGLION; VAGAL AFFERENT PATHWAY; GUINEA-PIG; ENZYME SECRETION; CCK ANTAGONIST; STIMULATION; POTENT; RECEPTORS; TERMINALS; L-364,718;
Keywords:
PANCREATIC GANGLION NEURON; MEMBRANE DEPOLARIZATION; CHOLECYSTOKININ; GASTRIN; CERULEIN; L-364,718; L-365,260; PANCREAS; CAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
R.C. Ma e J.H. Szurszewski, "CHOLECYSTOKININ DEPOLARIZES NEURONS OF CAT PANCREATIC GANGLION", Peptides, 17(5), 1996, pp. 775-783

Abstract

The effect of cholecystokinin octapeptide (CCK-8) on membrane potential and conductance of cat pancreatic ganglion neurons was studied in vitro by means of intracellular microelectrode recording methods. Microejection of S-CCK-8 and NS-CCK-8 evoked, by direct action, a slow, reversible membrane depolarization. The majority of neurons tested were more sensitive to S-CCK-8. The depolarizing response to S-CCK-8 and NS-CCK-8 was accompanied in different neurons by a variable change in membrane permeability to Na+ and/or K+. The effects of S-CCK-8 and NS-CCK-8 were mediated by the CCKB receptor. The results suggest that S-CCK-8 and NS-CCKB increase the excitability of pancreatic ganglion neuronsby acting on postsynaptic CCKB receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:20:09