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Titolo:
IRI-514, A SYNTHETIC PEPTIDE ANALOG OF THYMOPENTIN, REDUCES THE BEHAVIORAL-RESPONSE TO SOCIAL STRESS IN RATS
Autore:
MENZAGHI F; HEINRICHS SC; VARGASCORTES M; GOLDSTEIN G; KOOB GF;
Indirizzi:
SIBIA NEUROSCI INC,505 COAST BLVD S,SUITE 300 LA JOLLA CA 92037 SCRIPPS CLIN & RES INST,DEPT NEUROPHARMACOL LA JOLLA CA 92037 IMMUNOBIOL RES INST ANNANDALE NJ 08801
Titolo Testata:
Physiology & behavior
fascicolo: 2, volume: 60, anno: 1996,
pagine: 397 - 401
SICI:
0031-9384(1996)60:2<397:IASPAO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PUTATIVE NEUROTRANSMITTERS; POLYPEPTIDE HORMONE; FACTOR ANTAGONIST; NERVOUS-SYSTEM; INVITRO; ACETYLCHOLINE; THYMOPOIETIN; THYMUS; SECRETION;
Keywords:
RESIDENT-INTRUDER PARADIGM; SOCIAL STRESS; ELEVATED PLUS-MAZE; THYMIC PEPTIDE; ANXIETY; THYMOPENTIN; CORTICOTROPIN-RELEASING FACTOR; NICOTINIC RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
F. Menzaghi et al., "IRI-514, A SYNTHETIC PEPTIDE ANALOG OF THYMOPENTIN, REDUCES THE BEHAVIORAL-RESPONSE TO SOCIAL STRESS IN RATS", Physiology & behavior, 60(2), 1996, pp. 397-401

Abstract

Thymopentin, a synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) corresponding to amino acids 32-36 of the thymic polypeptide thymopoietin, has been reported to block adrenocorticotrope responses to stress. The purpose of the present study was to explore potential antistress properties of a synthetic analogue of thymopentin, IRI-514 (Ac-Arg-Pro-Asp-Phe-NH2) using a behavioral response to a stressor. The behavioral response to social conflict stress (resident-intruder paradigm) was evaluated by the elevated plus-maze test of anxiety in adult Wistar rats. A single subcutaneous (SC) administration of IRI-514, 48 h before stress, dose-dependently reversed the anxiety-like behavior induced by the social stress. The effect of IRI-514 was present over an extended period (24-72 h) following SC administration and was maximally effective at adose of 1 mg/kg. These results indicate that IRI-514 has a long-lasting modulatory effect on behavioral responses to a stressor, and suggest that thymopoietin-derived peptides may have a role in modulating both behavioral and neuroendocrine responses to stress.

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Documento generato il 08/07/20 alle ore 23:45:58