Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CLINICAL CORRELATES OF WHITE-MATTER FINDINGS ON CRANIAL MAGNETIC-RESONANCE-IMAGING OF 3301 ELDERLY PEOPLE - THE CARDIOVASCULAR HEALTH STUDY
Autore:
LONGSTRETH WT; MANOLIO TA; ARNOLD A; BURKE GL; BRYAN N; JUNGREIS CA; ENRIGHT PL; OLEARY D; FRIED L;
Indirizzi:
UNIV WASHINGTON,HARBORVIEW MED CTR,DEPT NEUROL,325 9TH AVE SEATTLE WA98104 UNIV WASHINGTON,DEPT NEUROL SEATTLE WA 98195 UNIV WASHINGTON,DEPT EPIDEMIOL SEATTLE WA 98195 UNIV WASHINGTON,DEPT BIOSTAT SEATTLE WA 98195 NHLBI,DIV EPIDEMIOL & CLIN APPLICAT BETHESDA MD 20892 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,DEPT PUBL HLTH SCI WINSTON SALEMNC 27103 JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,NEURORADIOL DIV BALTIMORE MD 21205 JOHNS HOPKINS UNIV,SCH MED,DEPT MED BALTIMORE MD 21205 UNIV PITTSBURGH,MED CTR,DEPT RADIOL & NEUROL SURG PITTSBURGH PA 00000 UNIV ARIZONA,CTR RESP SCI TUCSON AZ 00000 TUFTS UNIV NEW ENGLAND MED CTR,DEPT RADIOL BOSTON MA 02111
Titolo Testata:
Stroke
fascicolo: 8, volume: 27, anno: 1996,
pagine: 1274 - 1282
SICI:
0039-2499(1996)27:8<1274:CCOWFO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR RISK-FACTORS; MINI-MENTAL STATE; OLDER ADULTS; LESIONS; DISEASE; ROTTERDAM; DISEQUILIBRIUM; ABNORMALITIES; MRI;
Keywords:
AGED; COGNITION; HYPERTENSION; MAGNETIC RESONANCE IMAGING; WHITE MATTER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
W.T. Longstreth et al., "CLINICAL CORRELATES OF WHITE-MATTER FINDINGS ON CRANIAL MAGNETIC-RESONANCE-IMAGING OF 3301 ELDERLY PEOPLE - THE CARDIOVASCULAR HEALTH STUDY", Stroke, 27(8), 1996, pp. 1274-1282

Abstract

Background and Purpose Our aim was to identify potential risk factorsfor and clinical manifestations of white matter findings on cranial MRI in elderly people. Methods Medicare eligibility lists were used to obtain a representative sample of 5888 community-dwelling people aged 65 years or older. Correlates of white matter findings were sought among 3301 participants who underwent MRI scanning and denied a history of stroke or transient ischemic attack. Participants underwent extensive standardized evaluations at baseline and on follow-up, including standard questionnaires, physical examination, multiple blood tests, electrocardiogram, pulmonary function tests, carotid sonography, and M-mode echocardiography. Neuroradiologists graded white matter findings from 0 (none) to 9 (maximal) without clinical information. Results Many potential risk factors were related to the white matter grade, but in the multivariate model the factors significantly (all P < .01) and independently associated with increased grade were greater age, clinicallysilent stroke on MRI, higher systolic blood pressure, lower forced expiratory volume in 1 second (FEV(1)), and income less than $50 000 peryear. If excluded, FEV(1) was replaced in the model by female sex, history of smoking, and history of physician-diagnosed hypertension at the baseline examination, Many clinical features were correlated with the white matter grade, especially those indicating impaired cognitive and lower extremity function. Conclusions White matter findings were significantly associated with age, silent stroke, hypertension, FEV(1),and income. The white matter findings may not be considered benign because they are associated with impaired cognitive and lower extremity function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:27:58