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Titolo:
ANALYSIS OF DYNAMIC RADIOLIGAND DISPLACEMENT OR ACTIVATION STUDIES
Autore:
FRISTON KJ; MALIZIA AL; WILSON S; CUNNINGHAM VJ; JONES T; NUTT DJ;
Indirizzi:
NATL HOSP,WELLCOME DEPT COGNIT NEUROL,NEUROL INST,QUEEN SQ LONDON WC1N 3BG ENGLAND HAMMERSMITH HOSP,MRC,CYCLOTRON UNIT LONDON W12 0HS ENGLAND UNIV BRISTOL,PSYCHOPHARMACOL UNIT BRISTOL AVON ENGLAND
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 1, volume: 17, anno: 1997,
pagine: 80 - 93
SICI:
0271-678X(1997)17:1<80:AODRDO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BENZODIAZEPINE RECEPTORS; C-11 FLUMAZENIL; INVIVO; PET;
Keywords:
RADIOLIGAND BINDING; ACTIVATION STUDIES; FLUMAZENIL; STATISTICAL PARAMETRIC MAPPING; FUNCTIONAL NEUROCHEMISTRY; TIME-DEPENDENT COMPARTMENTAL MODELS; KINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Friston et al., "ANALYSIS OF DYNAMIC RADIOLIGAND DISPLACEMENT OR ACTIVATION STUDIES", Journal of cerebral blood flow and metabolism, 17(1), 1997, pp. 80-93

Abstract

We present a simple way of assessing dynamic or time-dependent changes in displacement during single-subject radioligand positron emission tomography (PET) activation studies. The approach is designed to facilitate dynamic activation studies using selective radioligands. These studies are, in principle, capable of characterising functional neurochemistry by analogy with the study of functional neuroanatomy using rCBF activation studies. The proposed approach combines time-dependent compartmental models of tracer kinetics and the general linear model used in statistical parametric mapping. This provides for a comprehensive, voxel-based and data-led assessment of regionally specific effects. The statistical model proposed in this paper is predicated on a single-compartment model extended to allow for time-dependent changes in kinetics. We have addressed the sensitivity and specificity of the analysis, as it would be used operationally, by applying the analysis to C-11-Flumazenil dynamic displacement studies. The activation used in thisdemonstration study was a pharmacological (i.v. midazolam) challenge,30 min after administration of the tracer. We were able to demonstrate, and make statistical inferences about, regional increases in k(2) (or decreases in the volume of distribution) in prefrontal and other cortical areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 20:49:39